At the current stage of genetic studies cattle, more and attention is being drawn to autochthonous breeds. Native cattle have a number prominent phenotypic traits preserved unique genes their combinations lost by modern commercial breeds, which would be valuable use in selective programs. We surveyed polymorphism Ukrainian Gray breed according alleles exon 2 BoLA-DRB3 gene. The uniqueness gene ...

this study was conducted to determine polymorphism of gola-drb3 in nadushan goat using pcr-rflp. blood samples were randomly taken from 100 goats. dna was extracted from the blood samples using diatom dna prep kit. spectrophotometer and 1% agarose gel were used for determining its quantities and qualities. exon 2 of drb 3.2 gene encompassing 285 bp was amplified with heminested-pcr method in tw...

To identify foot-and-mouth disease virus (FMDV) specific T-cell epitopes within the entire polyprotein sequence of the virus, 442 overlapping pentadecapeptides were tested in proliferation assays using lymphocytes from cattle experimentally infected with FMDV. Four months post-infection cells from all investigated animals (n = 4) responded by proliferation and interferon-gamma production to a p...

Tumors are believed to emerge only when immune surveillance fails. We wished to ascertain whether the failure to inherit putative protective alleles of HLA class II genes is linked to the development of breast cancer. We molecularly typed HLA DPB1, DQB1, DRB1, and DRB3 alleles in 176 Caucasian women diagnosed with early-onset breast cancer and in 215 ethnically matched controls. HLA DQB*03032 w...

The HLA region has long been implicated in sporadic and familial Hodgkin disease (HD), with recent case-control studies suggesting that HLA class II loci predispose to sporadic nodular sclerosis HD (NSHD). To determine whether this predisposition extends to familial HD, HLA class II loci (DRB1, DQA1, DQB1, DRB3, DRB4, and DRB5) and transporter associated with antigen processing (TAP) loci (TAP1...