keratoderma is a group of disorders characterized by abnormal thickening of skin. acquired palmar keratoderma has many underlying causes. the association of thyroid disease and palmar keratoderma rarely reported. hypothyroidism, although very rare association, must be suspected in patients with acquired ppk, particularly when it occurs in setting of systemic symptoms or predisposing conditions....

conclusions the current study indicated that h. pylori infection occurs at a higher rate in patients with down syndrome and mental retardation. this may provide more reasons to control the transmission of h. pylori among them. results the differences between the groups were compared by t-test and x2 test. seropositivity for h. pylori was significantly higher in patients with down syndrome and m...

BACKGROUND Sleep-disordered breathing is a common and serious feature of many paediatric conditions and is particularly a problem in children with Down syndrome. Overnight pulse oximetry is recommended as an initial screening test, but it is unclear how overnight oximetry results should be interpreted and how many nights should be recorded. METHODS This retrospective observational study evalu...

Research evidence suggests that, for typically developing children, spoken language and gesture develop alongside one another during early language development. Once children have begun to demonstrate two-word speech, there is a gradual reduction in new gesture learning and frequency of gesture use with increasing spoken language acquisition. Thus, though children do continue to use gesture, th...

[Purpose] To compare function, activity, participation, and quality of life of Down syndrome children and typically developing children according to age. [Subjects and Methods] A total of 16 Down syndrome children and 20 children with typical development were included as subjects for this study. International Classification of Functioning, Disability, and Health (ICF) Child and Youth version (C...

OBJECTIVES To assess whether children with Down syndrome in the US are at an increased risk for obesity, we determined the obesity prevalence and analyzed obesity development throughout childhood in a cohort of children with Down syndrome. In addition, we analyzed a comorbidity that is associated with Down syndrome and obesity, obstructive sleep apnea syndrome (OSAS). STUDY DESIGN This study ...

Spoken language in children with Down syndrome and in children in a normative group was compared. Growth trends, individual variation, sex differences, and performance on vocabulary, pragmatic, and grammar scales as well as MaxLU (maximum length of utterance) were explored. Subjects were 330 children with Down syndrome (age range: 1-5 years) and 336 children in a normative group (1;4-2;4 years;...

In May 2014, Evans et al1 reported that children with Down syndrome had lower rates of in-hospital death after cardiac surgery, compared with children without Down syndrome. Forty years ago, these results would have been unthinkable, as heart defects were not repaired in the majority of children with Down syndrome. However, as the field of cardiac surgery evolved, equal postoperative outcomes w...

OBJECTIVES To compare children with Down syndrome and children without Down syndrome and investigate whether there is a significant difference in the burden that is placed on the health care system between these two groups only in respect of the repair of congenital heart disease at Red Cross War Memorial Children's Hospital, Cape Town, South Africa. DESIGN This study is a retrospective case ...

BACKGROUND Child with Down's syndrome is an individual who is suitable and eligible to receive early intervention services. This study aimed to measure the family outcome among parents of Down syndrome children, on the impact of receiving early intervention and identify the factors influencing it. METHODS A cross sectional was conducted from April 2009 until January 2010 with a total of 125 p...