As a result of interaction with epithelial cells in the thymic cortex, immature CD4 1 8 1 (double positive, DP) thymocytes express relatively few T cell receptors (TCRs) and contain diminished numbers of coreceptor-associated p56 lck (lck) PTK molecules. As a result, TCR signal transduction in DP thymocytes is significantly impaired, despite its importance for repertoire selection. We report he...

Methods A randomized, double-blind, placebo-controled, parallelgroup, phase II study was conducted. Thirty-six subjects with LAR to DP were randomized to receive Pangraminâ PLUS, ALK, Dermatophagoides pteronyssinus (AIT-DP) or placebo for 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints included: total combined symptom+medication sc...

If G is a graph then a subgraph H is isometric if, for every pair of vertices u, v of H, we have dH(u, v) = dG(u, v) where d is the distance function. We say a graph G is distance preserving (dp) if it has an isometric subgraph of every possible order up to the order of G. We give a necessary and sufficient condition for the lexicographic product of two graphs to be a dp graph. A graph G is seq...

Location. The internship will take place at the " Institut de Mathématiques de Jussieu-Paris Rive Gauche " in Jussieu. Scientific context and objectives. A DP-ribbon is a topological cylinder (a sphere with two boundaries) with a distinguished core circle with a distinguished side and an arrangement of DP-ribbons is a finite family of at least two DP-ribbons pairwise attached as shown in Fig. 1...

We found a population of nonlymphoid cells expressing both CD4 and CD8 in peripheral blood mononuclear cells (PBMCs) of human T-cell leukemia virus type-I pX transgenic rats with autoimmune diseases. These cells, which showed a monocytic phenotype, were also found in wild-type rats, and their number increased by adjuvant-assisted immunization. GM-CSF increased the number of these double-positiv...

Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce IL-7 signals even when they express high levels of transgenic IL-7R on their surface, because IL-7R si...

Inner product structures are given for realizations of the positive spin ladder representations over the generalized unit disk Dp,q = U(p, q)/K. This is accomplished by combining previous results of the author with the construction of a family of holomorphic polynomials on Dp,q . These polynomials, which play a crucial role in the present work, are shown to be orthogonal with respect to Lebesgu...

OBJECTIVES To investigate the occurrence of nocturnal ischemic events in patients with obstructive sleep apnea syndrome (OSAS) and ischemic heart disease (IHD). BACKGROUND Although previous reports documented nocturnal cardiac ischemic events among OSAS patients, the exact association between obstructive apneas and ischemia is not yet clear. It is also not known what differentiates between pa...

The Tcrb locus is subject to a host of regulatory mechanisms that impart a strict cell and developmental stage-specific order to variable (V), diversity (D), and joining (J) gene segment recombination. The Tcrb locus is also regulated by allelic exclusion mechanisms, which restrict functional rearrangements to a single allele. The production of a functional rearrangement in CD4-CD8- double-nega...

Previous studies have revealed that HIV-infected individuals possess circulating CD4(+)CD8(+) double-positive (DP) T cells specific for HIV Ags. In the present study, we analyzed the proliferation and functional profile of circulating DP T cells from 30 acutely HIV-infected individuals and 10 chronically HIV-infected viral controllers. The acutely infected group had DP T cells that showed more ...