UNLABELLED This study is a retrospective analysis of 124 differentiated thyroid cancer patients who underwent dosimetric evaluation using MIRD methodology over a period of 15 y. The objectives of the study were to demonstrate the clinical use of dosimetry-guided radioactive iodine ([RAI] (131)I) treatment and the safe and effective application of a 3-Gy bone marrow (BM) dose in patients with di...

Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Portugal In order to ensure the safe usage of new radiopharmaceuticals in Positron Emission Tomography (PET), it is necessary to quantify the doses delivered to the organs and tissues within the patients’ bodies. A framework that allows estimating the dose delivered by PET has been established by the MIRD Committee ...

A Monte Carlo shielding model for PET/CT clinics Robert L. Metzger and Kenneth A. Van Riper Radiation Safety Engineering, Inc Chandler, AZ Abstract Modern PET/CT clinics consist of a scanner room housing the double gantry PET/CT unit and a control area, two or more quiet rooms where patients rest prior to scanning, and a hot lab where doses are prepared. Of these areas, the scanner room, quiet ...

Neutron dose-equivalent buildup factors were calculated for point isotropic neutron sources irradiating infinite slablike shields of lead, iron and water using the MCNP code. The factors are presented for some source neutron energies in the range from 0.025 eV to 14 MeV, and for shield thicknesses from 0.5 to 10 mfp. Since the MCNP code considers all kinds of neutron interactions with matter, a...

Background: Palladium-103 (103Pd) is a brachytherapy source for cancer treatment. The Monte Carlo codes are usually applied for dose distribution and effect of shieldings. Monte Carlo calculation of dose distribution in water phantom due to a MED3633 103Pd source is presented in this work. Materials and Methods: The dose distribution around the 103Pd Model MED3633 located in the center of 30×...

Anatomically accurate phantoms are useful tools for radiation dosimetry studies. In this work, we demonstrate the construction of a new generation of life-like mouse phantoms in which the methods have been generalized to be applicable to the fabrication of any small animal. The mouse phantoms, with built-in density inhomogeneity, exhibit different scattering behavior dependent on where the radi...

The development of novel, systemically administered radionuclide therapies (such as radioimmunotherapy) relies on the ability to predict dose-limiting toxicity to normal tissue. Where the kidney is the principal route of excretion of the radionuclide preparation and/or breakdown of products, nephrotoxicity may be the dose-limiting factor. Until recently, conventional (MIRD) dosimetry assumed th...