PURPOSE Clinical and 3D dosimetric parameters are associated with symptomatic radiation pneumonitis rates in retrospective studies. Such parameters include: mean lung dose (MLD), radiation (RT) dose to perfused lung (via SPECT), and pre-RT lung function. Based on prior publications, we defined pre-RT criteria hypothesized to be predictive for later development of pneumonitis. We herein prospect...

Introduction: The postmastectomy radiotherapy uses bolus to improve the coverage close to the skin; however, it needs to be removed in case of severe skin toxicity. This study investigated the effect of bolus parameters (i.e., frequency and thickness) for the superposition algorithm on skin dose in postmastectomy three-dimensional conformal radiotherapy (3D-CRT). <str...

BACKGROUND Radiation to the neck has long been associated with an elevated risk of hypothyroidism development. The goal of the present work is to define dosimetric predictors of hypothyroidism in oropharyngeal cancer (OPC) patients treated with intensity-modulated radiation therapy. METHODS Data for 123 patients, with a median follow up of 4.6 years, were retrospectively analyzed. Patients wi...

Stereotactic radiotherapy plays a major role in the treatment of brain metastases (BM). We aimed to compare dosimetric results four plans for hypofractionated stereotactic (HFSRT) large metastases. Ten patients treated with upfront NovalisTx® non-coplanar multiple dynamic conformal arcs (DCA) HFSRT ≥ 25 mm diameter single BM were included. Three other volumetric modulated arc therapy (VMAT) eva...