background: the role and proper dose of pralidoxime in the treatment of organophosphorus (op) compounds poisoning is an unresolved issue .this study was designed to compare the regimen recommended by the world health organization (who) with the commonly used standard regimen of pralidoxime. methods: this was a randomized open labeled prospective study on op poisoned patients admitted to jss hos...

background: gastric cancer is an important health problem across the world. chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. the purpose of this investigation was evaluation of response and tolerability to neoadjuvant eox regimen in locoregionally advanced gastric cancer. materials and methods: patients with locoregionally adv...

helicobacter pylori is the main cause of gastric ulcer, adenocarcinoma and mucosa-associated lymphoid tissue (malt) lymphoma. up to now, different regimens have been used for helicobacter pylori (h.pylori) eradication to find the most potent and cost-effective regimen with less side effects. the aim of this study was to investigate the efficacy of standard triple therapy versus quadruple therap...

First human administration of a new chemical entity (NCE) constitutes a critical step in drug development. The primary objective of such a study is the assessment of the shortterm safety and tolerability of single and multiple doses of the NCE in healthy volunteers. Secondary objectives are to obtain preliminary data on the pharmacokinetics and pharmacodynamics using surrogate or biornarkers of...

The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/kg) were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration, respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coli as test organism. The pharmacokinetic profiles fitted one-co...

The disposition kinetics and dosage regimen of cefepime were compared after its intravenous and intramuscular administration at 10 mg.kg-1 in healthy buffalo calves. The drug concentration in plasma was estimated by microbiological assay. The peak plasma concentration of cefepime after intravenous injection was at 1 min (46.4 ± 0.40 g.ml-1) and after intramuscular administration it was at afte...

The pharmacokinetics of intravenous ciprofloxacin and its metabolites were characterized in 42 subjects with various degrees of renal function (group 1, Clcr (mL/min/1.73 m2) > 90, n = 10; group 2, Clcr 61-90, n = 11; group 3, Clcr 31-60, n = 11; group 4, Clcr < or = 30, n = 10). The dosage regimens were-groups 1 and 2: 400 mg i.v. at 8 hourly intervals; group 3: 400 mg i.v. at 12 hourly interv...

Drug development is very time consuming and costly process. Only few candidates enters in to clinical trials can eventually become a drug. Accurate prediction of the right dose before entering in to clinical study can reduce time as well as cost of drug discovery process. Pharmacokinetic plays an essential role in the selecting the right dose and dosage regimen [1-5]. Thus early prediction of h...

Long-half-life drugs raise the hope of once-a-week administration of antituberculous treatment. In a previous study with the murine model of tuberculosis, the most active intermittent regimen which contained rifapentine (RFP), isoniazid (INH), and moxifloxacin (MXF) given once a week during 5.5 months, preceded by 2 weeks of daily treatment with INH, rifampin (RIF), pyrazinamide (PZA), and MXF,...

furazolidone (fzd), a nitrofuran derivative, is an antibacterial agent in use by the medical and veterinary fields. the chinese have utilized fzd to relieve stomach pain, 5 years before the discovery of helicobacter pylori. this drug is currently a part of helicobacter pylori's eradication regimen. however, some carcinogenic and toxic adverse effects associated with fzd have been observed in an...