The neurotransmitter dopamine has been implicated in the aetiology of brain disorders such as Parkinson’s disease and schizophrenia, and dopamine receptors provide important targets for anti-parkinsonian and antipsychotic drugs. In particular, the beneficial use of dopamine D2 or DI/D2 agonists in the drug treatment of Parkinson’s disease is now well established [l], although the ideal agonist ...

Aripiprazole, an atypical antipsychotic drug, is a D(2) dopamine-receptor partial agonist, but also has affinity to several serotonin receptors (5-HT(1A,2A,2C,7)). However, little is known about the contribution of serotonin receptors in the action of aripiprazole. The present study investigated the effects of aripiprazole on 5-HT(2A) receptor-mediated behaviors and compared them with the effec...

The gastrointestinal hormone PYY(3-36) is a preferential Y2 neuropeptide Y (NPY) receptor agonist. Recent evidence indicates that PYY(3-36) acts on central dopaminergic pathways, but its influence on dopamine-dependent behaviours remains largely unknown. We therefore explored the effects of peripheral PYY(3-36) treatment on the behavioural responses to novelty and to dopamine-activating drugs i...

CONTENTS 1. Introduction 230 2. Concepts of the functional role of striatal dOpaminergic activity 231 2.1. Introduction 231 2.2. The behavioural actions of dopamine in the striatum: unitary or diverse? 231 2.3. Regional differences in the striatal functions revealed by the actions of dopamine 232 2.4. The side to which the striatum's behavioural effects are referred 232 2.4.1. The traditional v...

The non-catechol, selective dopamine D2-agonist compound 3H-205-502 was used to localize dopamine D2 receptors by autoradiography after in vitro labeling of brain sections. The characteristics of the binding of this ligand to tissue sections were those expected from the labeling of dopamine D2 receptors. The binding of 3H-205-502 was inhibited selectively and stereospecifically by dopamine D2 a...

Orexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant-induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells. We examined the ability of dopamine agonists to activate orexin neurons ...

Hyperprolactinemia is a persistent excess of the blood serum prolactin. The syndrome contains various symptoms, most characteristic violation reproductive system. There are multiple endogenous and exogenous causes hyperprolactinemia. main treatment method dopamine agonist therapy, in case prolactinoma existence, surgical radiation methods can be applied. About 15% patients resistant to which de...

Dopamine receptor function in spontaneously hypertensive rats (SHR) and in control progenitor Wistar-Kyoto (WKY) rats was assessed from their dopamine D1-like/D2-like receptor-mediated jaw movements and dopamine release from the nucleus accumbens and from the ventrolateral striatum measured by an in vivo microdialysis technique. Spontaneous locomotor activity and rearing were significantly high...

In addition to dopamine neuron firing, cholinergic interneurons (ChIs) regulate dopamine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals. Synchronous activity of ChIs is necessary to evoke dopamine release through this pathway. The frequency-dependence of disynaptic nicotinic modulation has led to the hypothesis that nAChRs act as a high-pass filt...

Dopamine D(2) receptor partial agonist antipsychotic drugs can modulate dopaminergic neurotransmission as functional agonists or functional antagonists. The effects of antipsychotics on presynaptic dopaminergic functions, such as dopamine synthesis capacity, might also be related to their therapeutic efficacy. Positron emission tomography (PET) was used to examine the effects of the partial ago...