BACKGROUND Minimizing donor-site morbidity after free flap harvest is of paramount importance. In this article, we share our experience with achieving primary closure of 58 anterolateral thigh (ALT) free flap donor sites using a simple algorithm in cases where primary closure would otherwise have not been possible. METHODS Between 2004 and 2010, 58 patients who underwent free ALT flap reconst...

The versatile fasciocutaneous radial flap is robust and reliable, straightforward to harvest, and often produces a satisfactory reconstruction with relatively little long-term morbidity at the donor site. Many surgeons prefer to use a limited number of trusted flaps, and these qualities will ensure that in the intermediate future most surgical trainees will continue to be shown the fasciocutane...

Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy of manuka honey dressing with conventional dressing regarding skin graft donor sites...

Abstract While performing a tooth extraction surgery, removal of implants with incorrect orientation, or sinus lift choosing the best source of graft is always facing a challenge. Various options are available for obtaining grafts to reconstruct the defects. To make the wise choice in each case we should follow these  questions:Is autogenic grafts still the gold standard?  What are the b...

Primary closure of a large anterolateral thigh (ALT) flap donor site defect with the assistance of an external tissue expansion system is presented. The dimensions of this donor site (12 cm × 40 cm) and its percentage of leg circumference (34%) would make this site likely to require skin grafting or further flap coverage based on the results of previously published literature.

Several mutations are known or suspected to affect mRNA splicing of CYP2C19, CYP2D6 and CYP3A5 genes; however, little experimental evidence exists to support these conclusions. The present study applies mathematical models that measure changes in information content of splice sites in these genes to demonstrate the relationship between the predicted phenotypes of these variants to the correspon...

Many attempts have been made at donor site reconstruction to reduce postoperative pain following anterior cervical surgery. This study is a comparative analysis of the outcome of 46 patients undergoing single-level anterior corpectomy and fusion using iliac crest autograft performed by one surgeon (N.E.E.). Twenty-three patients had no donor site reconstruction, whereas the more recent 23 patie...

BACKGROUND  Reconstruction of complex soft tissue defects of the thumb, with exposure of tendons, joints or bones, has always been a difficult task. We evaluated the functional and esthetic outcomes of 1st dorsal metacarpal artery island flap in reconstruction of post-traumatic soft tissue defects of the thumb. METHODS Between January 2012 and June 2014, fifteen patients with co...

diabetes is characterized by a nitric oxide deficiency at the wound site. diabetes is a factor that influences all stages of wound healing. in animals with acute experimental diabetes induced by streptozotocin (stz), the early inflammatory responses after wounding is impaired, fibroblast and endothelial cell proliferation is reduced as well as accumulation of reparative collagen and gain in wou...