Huntington's disease (HD) is a fatal, dominant neurogenetic disorder. HD results from polyglutamine repeat expansion (CAG codon, Q) in exon 1 of HD, conferring a toxic gain of function on the protein huntingtin (htt). Currently, no preventative treatment exists for HD. RNA interference (RNAi) has emerged as a potential therapeutic tool for treating dominant diseases by directly reducing disease...

Within the group of maternal effect genes necessary for the establishment of the dorsal-ventral pattern of the Drosophila embryo, the Toll gene mutates to give a singular variety of embryonic phenotypes. Lack of function alleles produce dorsalized embryos as a recessive maternal effect. Dominant gain of function alleles result in ventralized embryos. Other recessive alleles cause partial dorsal...

The epitaxial growth of zinc-blende (cubic) GaN and InGaN on GaAs with a common cleavage plane and readily high-quality, low-cost wafers may be considered as an alternative approach for the future realization of cleaved laser cavities. To obtain detailed information about the potential of cubic GaN and InGaN for device applications we performed optical gain spectroscopy accompanied by time-inte...

In the context of conjugated polymers, especially those of the poly (phenylenevinylene) (PPV) family, which are promising candidates as emission material in light emitting devices such as LEDs, field effect transistors and photovoltaic devices, we have, in the present study, prepared MEH-PPV [Poly [2- methoxy-5-(2’-ethyl-hexyloxy)-1,4-phenylen-evinylene] of low molecular weight and low polydisp...

BACKGROUND Previous studies have shown a relationship between shoulder posterior capsule tightness and shoulder pain in overhead athletes. However, this relationship has not been studied in tennis players. OBJECTIVES Assessment of the shoulder range of motion (ROM), strength and posterior capsule tightness of skilled amateur tennis players who had complaints of dominant shoulder pain in compa...

In this work we propose space-multimode (SM-SCP-ULA) space-multimode-polarization stacked circular patch uniform linear antenna arrays (SMP-SCP-ULA) for deployment in size-constrained access points, modems and end-user terminal equipments of IEEE 802.11n MIMO-OFDM WLAN systems at 5.8 GHz. The performance gain of higher-order modal SMP-SCP-ULA in terms of spatio-modal power correlations, ergodic...

We compare the temperature dependent characteristics of multiple quantum well semiconductor laser diodes and light emitting diodes operating at a wavelength, /z = 1.3 ,um. No model in which Auger recombination is the dominant temperature sensitive parameter can explain our experimental observations. We suggest that net gain is the appropriate temperature dependent variable which determines lase...

A Bommel-Dransfeld technique is used to analyse the frequency spectrum in GaAs acousto­ electric domains up to 8 GHz. Parametric frequency conversion is found to be only dominant at the very onset of domain formation. In the strongly nonlinear regime, the amplified noise is mainly concentrated around the shifting frequency of maximum nonlinear gain. The shift of the maximum gain frequency is ge...