Abstract A self-regulatory genetic circuit, where a protein acts as a positive regulator of its own production, is known to be a simplest form of biological network with a positive feedback loop. Although at least three components, DNA, RNA, and the protein, are required to form such a circuit, the stability analysis of fixed points of the self-regulatory circuit has been performed only after r...

The self-assembly of nanoelectronic devices provide an opportunity to achieve unprecedented density and manufacturing scale in the post-Moore’s Law era. Bottom-up DNA self-assembly has emerged as a promising technique towards achieving this vision and it has been used to demonstrate precise patterning and functionalisation at resolutions below 20 nm. However, a lack of understanding of fabricat...

DNA nanostructures constitute attractive devices for logic computing and nanomechanics. An emerging interest is to integrate these two fields and devise intelligent DNA nanorobots. Here we report a reversible logic circuit built on the programmable assembly of a double-stranded (ds) DNA [3]pseudocatenane that serves as a rigid scaffold to position two separate branched-out head-motifs, a bimole...

The development of DNA circuits capable of adaptive behavior is a key goal in DNA computing, as such systems would have potential applications in long-term monitoring and control of biological and chemical systems. In this paper, we present a framework for adaptive DNA circuits using buffered strand displacement gates, and demonstrate that this framework can implement supervised learning of lin...

Signal amplification is a key component of molecular detection. Enzyme-free signal amplification is especially appealing for the development of low-cost, point-of-care diagnostics. It has been previously shown that enzyme-free DNA circuits with signal-amplification capacity can be designed using a mechanism called 'catalyzed hairpin assembly'. However, it is unclear whether the efficiency and m...

A monolithic circuit has been designed for active-quenching and active-reset of single-photon avalanche diodes (SPADs), which operate above the breakdown voltage BD for detecting single photons. To the best of our knowledge, this is the first fully integrated circuit of this kind ever reported. It can operate with any available SPAD device, since it generates pulses high enough to quench detect...

This paper provides a refinement of the minimum DNA computational model by [OR98b], which assumes the smallest set of permissible biochemical operations. The power of the refined model is characterized in terms of standard Boolean circuit complexity classes.

Reversible logic circuits are of interests to power minimization having applications in low power CMOS design, optical information processing, DNA computing, bioinformatics, quantum computing and nanotechnology. In this paper we propose a novel 4x4 bit reversible multiplier circuit. The proposed reversible multiplier is faster and has lower hardware complexity compared to the existing counterpa...

The amount of research on human aging and longevity has been growing rapidly in recent years. Multidisciplinary approaches, which integrate classic population genetics methods with the principles of epidemiological and demographic investigation, are emerging as powerful tools for disentangling the complex gene network which modulates human lifespan. We try to summarize the different approaches ...