Bimolecular collision rate of 8-anilinonaphthalene-1-sulfonic acid (ANS) and the nitroxide doxyl group attached to various carbons on stearic acid spin labels (n-SASL) in phosphatidylcholine-cholesterol membranes in the fluid phase was studied by observing dynamic quenching of ANS fluorescence by n-SASL's. The excited-state lifetime of ANS and its reduction by the n-SASL doxyl group were direct...

Rates of denitrification and nitrous oxide (N2O) formation, and the sources of N2 and N2O, were examined by the isotope-pairing technique in three U.K. estuaries (Colne, Humber, Conwy), which ranged from extremely nutrified to oligotrophic. Nitrous oxide concentrations were supersaturated throughout the year with annual averages of 603% in the Colne, 158% in the Humber, and 133% in the Conwy, i...

Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients. The etiology of DN loss in sporadic PD is unknown, although it is hypothesized that aberrant protein aggregation and cellular oxidative stress may promote DN degeneration. Homozygous mutations in DJ-1 were recently describe...

It is widely appreciated that macroand microvascular complications, rather than hyperglycemia per se, are major contributors to morbidity and mortality in diabetes. In this issue of Diabetes, Williams et al. (1) report the results of a meta-analysis of genetic data from three moderately sized studies of patients with type 1 diabetes (T1D) and nephropathy. This report illustrates several challen...

Purpose Anastrozole (ANS) is an aromatase inhibitor that is widely used as a treatment for breast cancer in postmenopausal women. Despite the wide use of ANS, it is associated with serious side effects due to uncontrolled delivery. In addition, ANS exhibits low solubility and short plasma half-life. Nanotechnology-based drug delivery has the potential to enhance the efficacy of drugs and overco...

Les agressions sexuelles portent atteinte à l’intégrité physique et psychologique des personnes qui en sont victimes et entraînent des conséquences néfastes. Le viol constitue la forme la plus accomplie de ces agressions. Cette étude rétrospective visait à répertorier les cas de violences sexuelles enregistrés auprès des greffes du tribunal et de la cour criminelle de Port-Gentil, et d’en donne...

BACKGROUND AND METHODS In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl(4) solution. The diameter and specific surface area of the ANs@TiNWs was measured. The TiNWs and ANs@TiNWs were then compared for their ability to adsorb protein and adhere to MG63 c...