RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 receptor, retaining good binding affinity, in the same nanomolar range as the free ligands. The antiproliferative activity of the conjugates was...

The thermodynamical partition function of the Duffin–Kemmer–Petiau theory is evaluated using the imaginary-time formalism of quantum field theory at finite temperature and path integral methods. The DKP partition function displays two features: (i) full equivalence with the partition function for charged scalar particles and charged massive spin 1 particles; and (ii) the zero mode sector which ...

AbstractIn this paper we present the full classification of symmetry-invariant solutions for Gibbons–Tsarev equation. Then use these to construct explicit expressions two-component reductions Benney’s moments equations, get Pavlov’s equation, and find integrable Ferapontov–Huard–Zhang system, which describes implicit two-phase dKP

In this paper we consider the discounted 0–1 knapsack problem (DKP), which is an extension of classical where a set items decomposed into groups three items. At most one item can be chosen from each group and aim to maximize total profit selected while respecting capacity constraint. The DKP relatively recent in literature. It was considered several works metaheuristics are implemented solve in...

We study massless Duffin-Kemmer-Petiau (DKP) fields in the context of Einstein-Cartan gravitation theory. In the case of an identically vanishing torsion (Riemannian space-times) we show that there exists local gauge symmetries which reproduce the usual gauge symmetries for the massless scalar and electromagnetic fields. On the other hand, similarly to what happens with the Maxwell theory, a no...

UNLABELLED BEST implements a Bayesian hierarchical model to jointly estimate gene trees and the species tree from multilocus sequences. It provides a new option for estimating species phylogenies within the popular Bayesian phylogenetic program MrBayes. The technique of simulated annealing is adopted along with Metropolis coupling as performed in MrBayes to improve the convergence rate of the M...

Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin cyclo(Phe-Leu). This study aimed reveal the potential synthesize diverse nonribosomal peptide polyketide other secondary metabolites different DKP after clarifying taxonomic position. Strain identified albus, it showed 100% 16S rRNA gene sequence similarities 95.5% ...

To investigate the reaction kinetics of the solid-state degradation process of enalapril maleate, a Fourier transform infrared microspectroscope equipped with thermal analyzer (thermal FT-IR microscopic system) was used. The isothermal stability study was conducted at 120-130 degrees C for 1-2 h and changes in the three-dimensional plots of the IR spectra of enalapril maleate with respect to he...