نتایج جستجو برای: dizocilpine

تعداد نتایج: 1373  

Journal: :Pharmacology, biochemistry, and behavior 2001
S B Harrod R W Flint D C Riccio

Two experiments using a state-dependent retention (SDR) design determined whether MK-801 blocked the acquisition and retention of an avoidance response. In Experiments 1 and 2, rats were trained and tested 30 min after injections of either saline or MK-801 (0.05 and 0.10 mg/kg, respectively). Two minutes after training, subjects were immediately tested, and in both experiments, the avoidance re...

Journal: :British journal of pharmacology 1994
M Yassin C N Scholfield

1. The role of glutamate in producing tissue damage during cerebral anoxia was investigated in brain slices using antagonists to the NMDA and AMPA receptor types. 2. Tissue function was assessed by field recordings of the synaptically evoked potentials elicited by stimulating the main afferent input to the olfactory cortex, the lateral olfactory tract. Anoxia was produced by bathing the slice i...

Journal: :Biochemical Society transactions 1995
M Qume A Misra S Zeman J L Boddy A J Cross P T Francis A W Procter D M Mann D M Bowen

Initial studies of dementia due to lobar atrophy (Pick's disease and Dementia of the Frontal Lobe Type, DFT) indicate neurochemical profiles distinct from that of Alzheimer's disease (AD) [1,2]. We have examined the cortical serotonergic profile of previously frozen human brains from control patients (n=27, 178: 1 O? , age 68 f 10 yrs, postmortem delay (PMD) 30 f 20 hrs, mean f s.d.) and patien...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
I O Medvedev O A Dravolina A Y Bespalov

The present study assessed the ability of various site-selective N-methyl-D-aspartate (NMDA) receptor antagonists to affect the discriminative stimulus properties of naloxone in morphine-dependent rats. Adult male Wistar rats were trained to discriminate 0.1 mg/kg of s.c. naloxone from saline using a Y-maze shock-avoidance procedure. Naloxone-appropriate responding was exhibited as a function o...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
M Hiramatsu H Murasawa T Nabeshima T Kameyama

The role of kappa opioid receptor agonists in learning and memory is controversial. In the present study, the effects of U-50,488H on scopolamine-, mecamylamine- and dizocilpine-induced learning and memory impairments in rats were investigated. Scopolamine (3.3 mumol/kg s.c.), a muscarinic cholinergic antagonist, and mecamylamine (40 mumol/kg s.c.), a nicotinic cholinergic antagonist, significa...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Rebecca J Ralph-Williams Virginia Lehmann-Masten Veronica Otero-Corchon Malcolm J Low Mark A Geyer

Stimulation of the dopamine (DA) system disrupts prepulse inhibition (PPI) of the acoustic startle response. On the basis of rat studies, it appeared that DA D2 receptors (D2Rs) rather than D1 receptors (D1Rs) regulate PPI, albeit possibly in synergism with D1Rs. To characterize the DA receptor modulation of PPI in another species, we tested DA D1R and D2R mutant mice with direct and indirect D...

2013
NADA SAMARI LOUIS DE SAINT-GEORGES GIUSEPPE PANI SARAH BAATOUT LUC LEYNS MOHAMMED ABDERRAFI BENOTMANE

During cortical development, N-methyl D-aspartate (NMDA) receptors are highly involved in neuronal maturation and synapse establishment. Their implication in the phenomenon of excitotoxicity has been extensively described in several neurodegenerative diseases due to the permissive entry of Ca2+ ions and massive accumulation in the intracellular co...

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