has learned about the mechanism and regulation of secretory transport in Malpighian tubules of the yellow fever mosquito. After a brief review of insect salt and water balance, the emphasis shifts to the mechanism of action of two families of diuretic hormones, the CRF-like diuretic peptides and the kinins. To appreciate how the function of Malpighian tubules is integrated in the diverse activi...

With numerous safe and effective antihypertensive drugs now available, the clinician should no longer choose only diuretic agents or beta-adrenergic receptor blockers (beta-blockers) as initial therapy. Five classes of agents, including angiotensin converting enzyme inhibitors, beta-blockers, calcium entry blockers, peripheral alpha 1-adrenergic receptor blockers, and thiazide diuretic agents, ...

in the following notes the term digitalis is used to describe the entire group of cardiac glycosides a large number of plants contain cardiac glycosides, and these have been used by natives as arrow and ordeal poisons Squill was known to the ancient Egyptians and the Romans used it as a diuretic, heart tonic, emetic and rat poison Strophanthus was introduced by Sir Thomas Fraser in 1890 digital...

The discovery of the countercurrent multiplier system as the mechanism responsible for the concentration and dilution of the urine has provided a framework for the identification of the site of action of diuretic drugs. Agents that act at a single anatomic site in the nephron can be expected to alter the pattern of urine flow in a predictable way. A drug that acts solely in the proximal convolu...