Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...

Tetraethylthiuram disulfide (disulfiram) stimulated medium acidification when added at a concentration of 0.4 millimolar to illuminated or nonilluminated suspensions of Asparagus sprengeri Regel mesophyll cells. Similar concentrations inhibited photosynthesis and cyanide-resistant respiration. The reduction product of disulfiram, diethyldithiocarbamic acid, accumulated in concentrations suffici...

was the purpose of our double-blind, placebo-controlled study to verify the efficacy of cyanamide in the treatment of adolescent alcohol abusers (Niederhofer et al., 2003). Cyanamide is registered for the treatment of alcohol misusers; we therefore thought it would be appropriate to ascertain its efficacy, and in particular its safety, in adolescents. Disulfiram 442 The Randomised Controlled Tr...

This paper reviews the controlled studies which have led to the increasing recognition that supervised disulfiram is one of the few demonstrably effective interventions in alcoholism, both alone and as an adjunct to psychosocial methods. The specifically behavioural implications of disulfiram treatment are also noted. It examines techniques for maximising disulfiram's therapeutic effectiveness ...

Stoicheiometric amounts of [14C]disulfiram react rapidly with sheep liver cytoplasmic aldehyde dehydrogenase to give loss of catalytic activity and incorporation of the expected amount of radioactivity. In a subsequent slower reaction the label is lost from the enzyme without re-emergence of enzymic activity. The results imply that in vivo disulfiram may act as an oxidation-reduction catalyst f...

AIMS The tryptophan metabolites 3-hydroxykynurenine (3-HK) and 3-hydroxyanthranilic acid (3-HAA) inhibit the liver mitochondrial low Km aldehyde dehydrogenase and possess alcohol-aversive and immunosuppressant properties. As the disulfiram (DS) metabolite carbon disulphide activates enzymes forming 3-HK and 3-HAA, we investigated if repeated disulfiram treatment increases the hepatic and serum ...