Globoid cell leukodystrophy (GLD) or Krabbe disease, is a fatal demyelinating disease attributed to mutations in the galactocerebrosidase (GALC) gene. Loss of function mutations in GALC result in accumulation of the glycolipid intermediate, galactosylsphingosine (psychosine). Due to the cytotoxicity of psychosine, it has been hypothesized that accumulated psychosine underlie the pathophysiology...

The Pumilio and FBF (PUF) family of RNA-binding proteins interacts with protein partners to post-transcriptionally regulate mRNAs in eukaryotes. The interaction between PUF family member fem-3 binding factor (FBF) and germline development defective-3 (GLD-3) protein promotes spermatogenesis in Caenorhabditis elegans by increasing expression of the fem-3 mRNA. Defined here in these studies is th...

Following infection with the protozoan parasite Leishmania major, C57BL/6 mice develop a small lesion that heals spontaneously. Resistance to infection is associated with the development of CD4(+) Th1 cells producing gamma interferon (IFN-gamma) and tumor necrosis factor (TNF), which synergize in activating macrophages to their microbicidal state. We show here that C57BL/6 mice lacking both TNF...

A class of pseudo-random compound error-correcting codes, called Generalized Low-Density (GLD) Parity-Check codes, has been proposed recently. As a generalization of Gallager’s Low-Density ParityCheck (LDPC) codes, GLD codes are also asymptotically good in the sense of minimum distance criterion and can be effectively decoded based on iterative soft-input soft-output (SISO) decoding of individu...

The STAR family comprises ribonucleic acid (RNA)-binding proteins that play key roles in RNA-regulatory processes. RNA recognition is achieved by a KH domain with an additional α-helix (QUA2) that seems to extend the RNA-binding surface to six nucleotides for SF1 (Homo sapiens) and seven nucleotides for GLD-1 (Caenorhabditis elegans). To understand the structural basis of this probable differen...

As a class of pseudorandom error correcting codes, generalized low-density (GLD) codes exhibit excellent performance over both additive white Gaussian noise (AWGN) and Rayleigh fading channels. In this paper, distributed GLD codes are proposed for multiple relay cooperative communications. Specifically, using the partial error detecting and error correcting capabilities of the GLD code, each re...

To ensure the gear precision, industries need a coherent model to express, to analyse and to check geometrical specifications. Most gear tolerance representations are directly driven by the convenience of dimensional metrology and not by the convenience of the set of activities of the tolerancing process. Therefore, to ensure the coherence of all tolerancing process activities, there is a neces...

The glucose dehydrogenase genes (Gld) of Drosophila melanogaster, of D. pseudoobscura, and of D. virilis have been isolated and compared with each other in order to identify conserved and divergent aspects of their structure and expression. The exon/intron structure of Gld is conserved. The Gld mRNAs are similar, with a range of 2.6-2.8 kb among the three species. All three species exhibit peak...

Agents of transmissible spongiform encephalopathy (prion) are known to be extremely resistant to physicochemical inactivation procedures such as heat, radiation, chemical disinfectants such as detergents, alcohols, glutaraldehyde, formalin, and so on. Because of its remarkable resistance, it is difficult to inactivate prion. Chemical inactivation seems to be a practical method because it is app...

Using alternative materials such as residual products from other industries to mitigate the negative effects of acid rock drainage would simultaneously solve two environmental problems. The main residual product still landfilled by sulphate paper mills is the alkaline material green liquor dregs (GLD). A physical, mineralogical and chemical characterization of four batches of GLD was carried ou...