During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2. Evidence indicates that suppression of Oct4 expression in the trophectoderm is mediated by Cdx2. Nonetheless, the underlying epigenetic modifiers required for Cdx2-dependent repression of Oct4 are largely unknown....

Knowledge distillation (KD) is widely applied in the training of efficient neural network. A compact model, which trained to mimic representation a cumbersome model for same task, generally obtains better performance compared with being ground truth label. Previous KD-based works mainly focus on two aspects: (1) designing various feature knowledge transfer; (2) introducing different mechanism s...

In Table 1, the Kd values of ch14.18 for OAcGD2 and GD2 are incorrectly switched. The Kd value of OAcGD2 is 626 6 180 and the Kd value of GD2 is 22.6 6 2.2. Please see the correct Table 1 here. Copyright: ß 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproductio...

Signal recognition particle (SRP) and SRP receptor are known to be essential components of the cellular machinery that targets nascent secretory proteins to the endoplasmic reticulum (ER) membrane. Here we report that the SRP receptor contains, in addition to the previously identified and sequenced 69-kD polypeptide (alpha-subunit, SR alpha), a 30-kD beta-subunit (SR beta). When SRP receptor wa...

Oxidative stress and selenoprotein deficiency are thought to be associated with the pathogenesis of Keshan disease (KD). However, to our knowledge, the level of oxidative stress and expression of selenoproteins have not been investigated in the myocardium of patients with KD. In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of oxidative stress, was used to assess the level of oxid...

Dendritic cell (DC) activation and cytokine production is tightly regulated. In this study, we found that Zbtb10 expression dependent it essential for the immunogenic function of cDC1. knockdown (KD) significantly reduced co-stimulatory genes CD80 CD86 along with cytokines including IL-12, IL-6, IL-10, in activated cDC1 Mutu-DC line. Consequently, clonal expansion CD44+ effector T cells co-cult...

Phosphatidylinositol-3-kinase gamma (PI3Kγ) is a leukocyte-specific lipid kinase with signaling function downstream of G protein-coupled receptors to regulate cell trafficking, but its role in T cells remains unclear. To investigate the requirement of PI3Kγ kinase activity in T-cell function, we studied T cells from PI3Kγ kinase-dead knock-in (PI3Kγ(KD/KD)) mice expressing the kinase-inactive P...