We show that the disintegration operator on a complete separable metric space along a projection map, restricted to measures for which there is a unique continuous disintegration, is strongly Weihrauch equivalent to the limit operator Lim. When a measure does not have a unique continuous disintegration, we may still obtain a disintegration when some basis of continuity sets has the Vitali cover...

The type and the amount of binders decisively influence the characteristics of tablets prepared by wet granulation procedure. Commonly used binders like acacia, gelatin, starch and hydrolyzed starch have natural origin. The aim of this study was to evaluate the effectiveness of a new binder extracted from Hibiscus esculentus (Okra gum) in tableting. binder Hibiscus esculentus gum was extracted ...

The mechanical and disintegration properties of paracetamol tablets formulated using Delonix regia seed gum (DRSG) as a binder have been studied in this work. Acacia BP (ACG) and tragacanth BP (TRG) were used as official gum standards. The mechanical properties, i.e. tensile strength (TS) and brittle fracture index (BFI), showed that with an increase in concentration of the gum binder, the tens...

The objective of this study was to evaluate the performance of Sucro Ester 7 (sucrose distearate) as additive for preparing sustained release suppositories of tiaprofenic acid. Suppocire AIM (semi-synthetic glycerides) was used as suppository base and formulations were prepared containing different ratios of sugar ester: Suppocire AIM. Content uniformity, disintegration time and in vitro releas...

The USP General Chapter <2040> Disintegration and Dissolution of Dietary Supplements introduced a rupture test as a performance test of soft-shell capsules. Traditionally, the disintegration test was used for determining the disintegration time of all solid oral dosage forms. The aim of this investigation was to investigate differences between the rupture test and the disintegration test using ...

The type and the amount of binders decisively influence the characteristics of tablets prepared by wet granulation procedure. Commonly used binders like acacia, gelatin, starch and hydrolyzed starch have natural origin. The aim of this study was to evaluate the effectiveness of a new binder extracted from Hibiscus esculentus (Okra gum) in tableting. binder Hibiscus esculentus gum was extracted ...

This study evaluates the disintegrant properties--tablet disintegration time (DT) and crushing strength--friability/disintegration time (CSFR/DT) ratio of a paracetamol tablet formulation prepared with sorghum and plantain starches in comparison with corn starch BP. The effects of disintegrant concentration, relative density of tablets and the mode of disintegrants addition were studied. The st...

The polyherbal decoction, Gulugulutitakam is known for the treatment of various inflammatory conditions. For the ease of administration, this dosage form has been converted into tablets containing high amount of dry extract but it has the disadvantage of longer disintegration and dissolution parameters. In our attempt to develop tablets with improved disintegration and dissolution time, we have...