The USP General Chapter <2040> Disintegration and Dissolution of Dietary Supplements introduced a rupture test as a performance test of soft-shell capsules. Traditionally, the disintegration test was used for determining the disintegration time of all solid oral dosage forms. The aim of this investigation was to investigate differences between the rupture test and the disintegration test using ...

Fast dissolving film of levocetrizine dihydrochloride were prepared by solvent casting method by using Maltodextrin & HPMC E15 as the main film forming polymers.To decrease the disintegration time,concentration of maltodextrin & HPMC E15 were optimized be using 2 factorial design. Disintegration time, drug release pattern, mouth dissolving time and content uniformity were also evaluated. Compat...

the physicochemical properties of Iranian acetyl salicylic acid(ASA) tablets,including the products of 10 manufacturers with 14 products,from each 3 batches,totally 42 products have been studied.the properties under investigation are hardness,friability percintage,humidity percentage,free salicylic acid,content uniformity,amount of ASA disintegration time,and released percentage.the results ind...

Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as Agar, gum karaya, platago ovata on disintegration time was studied. T...

Various half-scale and lab-scale investigations have already shown that the disintegration of excess sludge is a possible pre-treatment to optimise anaerobic digestion. To verify these results, different methods of disintegration were investigated at a full-scale plant. Two stirred ball mills, a plant for oxidation with ozone, a lysate centrifuge and an ultrasonic homogeniser were applied. A po...

The experimental results on the behaviour of the characteristics of secondary particles depending on the disintegration degree of nuclei are used to determine the region of central collisions. It was therefore possible that : – the correlation between the prosesses of total disintegration of nuclei and the central collisions of nuclei had been shown; – the existence of the regime change points ...