Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsa...

In situ end-labeling (ISEL) identifies DNA fragmentation in apoptotic or necrotic nuclei in tissue sections. However, application of ISEL on human brain requires conservation of DNA integrity during the postmortem delay (PMD) and good accessibility of fragmented DNA after (prolonged) tissue fixation. We therefore investigated ISEL in relation to PMD and fixation in rat and human brain. Applicat...

The dorsal premotor cortex (PMd) is abnormally active in patients with idiopathic Parkinson's disease. This has been interpreted as a functional correlate of adaptive plasticity within the motor system to compensate for deficient activation of striato-mesial-frontal projections in these patients. Whether abnormal PMd activity influences excitability in the primary motor cortex (M1) in untreated...

OBJECTIVE Pelizaeus-Merzbacher disease (PMD) is a progressive and lethal leukodystrophy caused by mutations affecting the proteolipid protein (PLP1) gene. The most common cause of PMD is a duplication of PLP1 and at present there is no curative therapy available. METHODS By using transgenic mice carrying additional copies of Plp1, we investigated whether curcumin diet ameliorates PMD symptoms...

Oral potentially malignant disorders (PMDs) are at risk of transforming to invasive squamous cell carcinoma (SCC), but controversy exists over their management and the precise role of interventional treatment. In this study, a cohort of 100 patients presenting with new, single oral dysplastic PMD lesions were followed for up to 10 years following laser excision. PMDs presented primarily as homo...

The topic of thesis is “Compensation of Polarization Mode Dispersion (PMD)” in Fiber optics communication and its impact on high speed data transmission. The work can be divided into three parts which deals with major aspects of PMD: characteristics, transmission and compensation. Polarization-mode dispersion (PMD), in single-mode optical fibers, is a phenomenon that a limit the bit-rate-distan...

We describe five boys from different families with an atypically severe form of Pelizaeus-Merzbacher disease (PMD) who have three, and in one case, five copies of the proteolipid protein (PLP1) gene. This is the first report of more than two copies of PLP1 in PMD patients and clearly demonstrates that severe clinical symptoms are associated with increased PLP1 gene dosage. Previously, duplicati...

With the development of high-speed, longdistance optical fiber communication systems, single-mode fiber polarization mode dispersion (PMD: Polarization mode dispersion) becomes one of the important factor limiting high-speed, long-distance optical fiber transmission. Polarization mode dispersion can cause pulse broadening in thedigital transmission system, result inter-symbol interference in di...

INTRODUCTION In adults who do not stutter (AWNS), the control of hand movement timing is assumed to be lateralized to the left dorsolateral premotor cortex (PMd). In adults who stutter (AWS), the network of speech motor control is abnormally shifted to the right hemisphere. Motor impairments in AWS are not restricted to speech, but extend to non-speech orofacial and finger movements. We here in...

The detection of an optical signal using a photonic mixer device (PMD) as an alternative to the PIN photodiode for a high-speed infrared link is discussed. The PMD, at its linear range, is characterized as a correlator detector. The functionality of this PMD for a better Signal-to-Noise Ratio is described. With an improved mixing efficiency and photosensitive area, the PMD will replace the use ...