Depression is common and may occur at any stage in the long history of Parkinson’s disease, markedly affecting a patient’s threshold to discomfort, but it is particularly difficult to assess before clear clinical features are evident. The rate of depression in patients with Parkinson’s disease vary, partly because of differences in the definition of depression, difficulties in distinguishing be...

The goal in studies concerning biomarkers in autoimmune diseases is finding a marker which fluctuates in correlation with the disease’s severity and settles within normal borders after effective treatment. This marker would later be used as an efficient tool in diagnosis and analysis of medicine clout. It seems the most cogent biomarkers are those measurable in serum or plasma. MS is a neurolog...

Depression is common and may occur at any stage in the long history of Parkinson’s disease, markedly affecting a patient’s threshold to discomfort, but it is particularly difficult to assess before clear clinical features are evident. The rate of depression in patients with Parkinson’s disease vary, partly because of differences in the definition of depression, difficulties in distinguishing be...

background: the clinical course of multiple sclerosis (ms) evolves over many years. its prognosis is highly variable among affected individuals, i.e. while some suffer from early severe disabilities, others remain ambulatory and functional for many years. we used multiple sclerosis severity score (msss) and the new classification for ms severity herbert et al. introduced in 2006 according to ms...

OBJECTIVES Joint pain and radiographic osteoarthritis are often discordant. AIM To investigate this issue more closely by studying the detailed nature of pain and disability, and how this relates to radiographic osteoarthritis. METHODS Population-based study of 819 adults aged >or=50 years with knee pain. The severity of knee pain, stiffness and disability was measured using a validated sca...

OBJECTIVE To assess potential racial and socioeconomic disparities in patients with parkinsonism treated at a tertiary Movement Disorders Center. METHODS Patients with parkinsonism were evaluated for demographics (age, race, annual income, and educational level), medical comorbidities, medication regimen, disability (Older Americans Resources and Services subscale), presence of Parkinson dise...

Background Cognitive dysfunction is a predominant symptom of Major Depressive Disorder (MDD), contributing to functional impairment. Objective The primary objective of this study was to assess and describe perceived cognitive dysfunction amongst Asian patients diagnosed with MDD. The secondary objective was to explore the associations between depression severity, perceived cognitive dysfuncti...