To improve the oral bioavailability of poorly water-soluble cyclosporin A (CyA), polymeric micelles based on monomethoxy poly(ethylene glycol)-b-poly(D,L-lactic acid) (mPEGPLA) were prepared. In vitro release test showed that the cumulative release percentage, about 85%, of CyA from polymeric micelles within 24 h was comparable to that from Sandimmun Neoral, the currently available oral formula...

the nanocomposites of poly (acryl amide-co-acrylic acid) with different contents of naazeolite were prepared using ammonium persulfate as an initiator and n, n′-methylenebisacrylamide as the crosslinker. the morphology was characterized by sem and the structure ofnanocomposite materials was studied with xrd and ft-ir that showed the interaction betweenporous materials and poly (aam-co-aac). the...

Stacking of β-sheets results in a protein super secondary structure with remarkable mechanical properties. β-Stacks are the determinants of a silk fiber's resilience and are also the building blocks of amyloid fibrils. While both silk and amyloid-type crystals are known to feature a high resistance against rupture, their structural and mechanical similarities and particularities are yet to be f...

Microcellular foams with unique cellular structures were prepared from poly(lactic acid) (PLA) and poly(butylene succinate-co-adipate) (PBSA) blends using a foam injection molding technique core-back operation. PLA PBSA are biopolymers that partially miscible each other. When these blended, several blend morphologies appeared found to be dependent on the ratio. The thermal rheological propertie...

Blend proton exchange membranes (BPEMs) were prepared by blending sulfonated poly(aryl ether nitrile) (SPAEN) with phosphorylated poly(vinylbenzyl chloride) (PPVBC) and named as SPM-x%, where x refers to the proportion of PPVBC weight SPAEN. The chemical complexation interaction between phosphoric acid sulfonic groups in PPVBC–SPAEN system resulted BPEMs reduced water uptake enhanced mechanical...

background: opioid abuse is common in iran. in recent years, methadone maintenance therapy (mmt) has gained popularity in this country. this study aimed at evaluation concurrent abuse of alcohol in patients under mmt. methods: a predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under mmt in kian rehabilitation centre during january 2014. resu...

in order to reduce the costs associated with poly-β-hydroxybutyrate production, growth and poly-β-hydroxybutyrate production of ralstonia eutropha were studied in batch culture on different carbon sources. experiments were designed and conducted to not only lower the cost of poly-β-hydroxybutyrate production by using inexpensive substrates, but also to increase poly-β-hydroxybutyrate production...

Sequential doping of 1 mm3 sized cubes regio-regular poly(3-hexylthiophene) (P3HT) with 2,3,5,6-tetrafluoro-tetracyanoquinodimethane is found to result in a gradient. The dopant ingresses into the solid material and after two weeks sequential yields 250 ?m thick doped surface layer, while interior remains undoped. gradient mapped energy dispersive x-ray spectroscopy (EDX), which used estimate d...