INTRODUCTION The risk of rheumatoid arthritis (RA) associated with dipeptidyl peptidase-4 inhibitor (DPP-4i) use is unclear. This study assesses the RA risk associated with DPP-4i use among a diabetic cohort initiating second-line therapy. METHODS This was a nested case-control study, using the adult diabetic population starting second-line antidiabetic therapy from IMS LifeLink Plus® databas...

BACKGROUND Metformin is an oral antidiabetic drug (OAD) widely used as first-line therapy in type 2 diabetes (T2D) treatments. Numerous treatment pathways after metformin failure exist. It is important to understand how treatment choices influence subsequent therapy progressions. This retrospective study compares adherence to, persistence with, and treatment progression in sulfonylurea (SU) and...

Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population because of their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here, we report five Japanese cases of BP associated with the ...

Dipeptidyl peptidase IV (DPP IV) is a serine exopeptidase that cleaves X-proline dipeptides from the N terminus of polypeptides. Dipeptidyl peptidase IV enzyme activity has been implicated in the regulation of the biological activity of multiple hormones and chemokines, including the insulinotropic peptides glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP). H...

Proline at the second position of the N-terminus of biologically active peptides involved in cell growth regulation is an evolutionarily conserved motif protecting them against cleavage by non-specific proteases. Just a small number of proline-specific hydrolases including dipeptidyl peptidase IV (DPP-IV) and related molecules is capable of cleaving such post-prolyl bond. DPP-IV, originally des...

Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K(+) channels that, in addition to enhancing channel surface expression, potently accelerates their kinetics. The dipeptidyl-peptidase 6 gene has been associated with a number of human central nervous system disorders including autism spectrum disorders and schizophrenia. Here we employ knockdown and genetic deletion of dipep...

OBJECTIVES Dipeptidyl peptidase IV (CD26; E.C. 3.4.14.5) is plasma membrane glycoprotein exopeptidase. There are no data on both phenotypic or genotypic expression and polymorphism of DPP-IV in Indian type-2 diabetic patients. Therefore we estimated the dipeptidyl peptidase IV (DPP-IV) levels in Indian type 2 diabetic population. METHODS Selection of study group was as follows: 1. Twenty seve...

Type 2 diabetes is a chronic metabolic derangement that results from defects in both insulin action and secretion. New thiazolidinedione insulin sensitizers have been recently launched. New approaches with mechanisms different from current therapies are being explored, including novel ligands of peroxisome proliferator-activated receptor, glucagon receptor antagonists, dipeptidyl peptidase IV i...

Cite this article: Reinhold D, Kähne T, Brocke S (2016) Competitive Antagonists of Adenosine Deaminase versus Enzymatic Inhibitors: Complementary Approaches Targeting Dipeptidyl Peptidase 4 (DP IV) and their Relation to MERS-CoV Infection. Ann Clin Cytol Pathol 2(3): 1028. *Corresponding author Stefan Brocke, Department of Immunology, University of Connecticut Health Center, Farmington, CT 0603...