The pyruvate dehydrogenase complex (PDHC) and its phosphorylation are considered essential for oncotransformation, but it is unclear whether cancer cells require PDHC to be functional or silenced. We used specific inhibition of PDHC by synthetic structural analogs of pyruvate to resolve this question. With isolated and intramitochondrial PDHC, acetyl phosphinate (AcPH, KiAcPH = 0.1 μM) was a mu...

The structures of diphenyl [3-methyl-1-(3-phenylthioureido)butyl]phosphonate and diphenyl [2-methyl-1-(3-phenylthioureido)butyl]phosphonate, both C(24)H(27)N(2)O(3)PS, are reported. In both compounds, the thiourea moiety adopts a syn-syn conformation (i.e. the S-C-N-C torsion angles are synperiplanar), which enables N-H...O hydrogen bonds to be formed between centrosymmetrically related molecul...

Nocardia cultures, isolated from soil by use of n-paraffins as the sole carbon source, have been shown to bring about significant oxidation of several methyl-substituted mono- and dicyclic aromatic hydrocarbons. Oxygen uptake by washed cell suspensions was not a reliable indicator of oxidation. Under co-oxidation conditions in shaken flasks, o- and p-xylenes were oxidized to their respective mo...

The synthesis of series of tripodal ligands: N,N-bis((3-carboxyethyl-5-dimethyl-1H-pyrazol-1yl)methyl)phenylamine L1, N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)phenylamine L2, N,N-bis((3carboxyethyl-5-dimethyl-1H-pyrazol-1-yl)methyl)pyridin-2-ylamine L3, N,N-bis((3,5-dimethyl-1H-pyrazol1-yl)methyl)pyridin-2-amine L4, N,N-bis((3-carboxyethyl-5-dimethyl-1H-pyrazol-1-yl)methyl)-2nitrophenylamin...

The present investigation deals with histopathological and histochemical studies of profenophos on liver and kidney of male albino rats and the protective effects of vitamin C and ginseng to reduce the deleterious effect induced by profenophos. Oral administration of profenophos at dose level of 1 /10 LD50 for 15 successive days induced histological changes in liver and kidney. No histological ...

The explosive growth of multimedia services and applications (e.g. media streaming) demands an efficient, deployable media distribution system on the Internet. Although native IP multicast is regarded as an efficient way of delivering media streams to a group of receivers, it faces a number of technical and operational issues which have eventually prevented its widespread usage. The aim of this...