Indentation hardness has been used extensively for material characterization and many recent computational studies have established quantitative relationships between elasto-plastic mechanical properties and the response in instrumented indentation. In contrast, very few studies have systematically quantified the effect of the plastic deformation characteristics on the frictional sliding respon...

Iterative solvers are of increasing interest in geomechanics with the move towards 3D finite element modelling. Potentially, these methods can lead to reduced computational complexity as, unlike direct methods, they do not require the full system matrix to be assembled. In general, however, iterative solvers have not been widely adopted in geomechanics due to problems with convergence. This pap...

In this article, we discuss the numerical solution of a constrained minimization problem arising from the stress analysis of elasto-plastic bodies. This minimization problem has the flavor of a generalized non-smooth eigenvalue problem, with the smallest eigenvalue corresponding to the load capacity ratio of the elastic body under consideration. An augmented Lagrangian method, together with fin...

Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to asses...

a two dimensional generalized thermoelastic problem of a thick circular plate of finite thickness and infinite extent subjected to continuous axisymmetric heat supply and an internal heat generation is studied within the context of generalized thermoelasticity. unified system of equations for classical coupled thermoelasticity, lord-shulman and green-lindsay theory is considered. an exact solut...

A new numerical approach is proposed for the simulation of coupled three-dimensional and one-dimensional elliptic equations (3D-1D coupling) arising from dimensionality reduction 3D-3D problems with thin inclusions. The method based on a well posed mathematical formulation results in scheme high flexibility handling geometrical complexities. This achieved by means three-field to split 1D bulk 3...