This paper and our conference paper (Abbott, Altenkirch, Ghani, and McBride, 2003b) explain and analyse the notion of the derivative of a data structure as the type of its one-hole contexts based on the central observation made by McBride (2001). To make the idea precise we need a generic notion of a data type, which leads to the notion of a container, introduced in (Abbott, Altenkirch, and Gha...

BBB blood-brain barrier BMEC brain microvascular (capillary) endothelial cells CBSA cationic bovine serum albumin CdTe cadmium tellurium CTAB trimethylammonium bromide DRG dorsal root ganglia HSA human serum albumin ip intraperitoneal iv intravenous MWCNT multi-walled carbon nanotube PAMAM poly(amidoamine) PBCA polybutylcyanoacrylate PEG polyethylene glycol PLA poly(lactide) PLGA poly(lactic-co...

1 A lter for edge detection In graylevel images boundaries are often associated to step-like discontinuities. In its simplest form the problem of nding boundaries in 1D images may therefore be thought of as the problem of nding step-discontinuities in a signal. The naive approach to this problem is to use a diierentiator and a threshold in series. The derivative of the signal ought to present l...

Hydraulic fracturing has received abundant media attention in recent years due to a rapid increase in the use of the technique in combination with horizontal drilling technology to produce oil and gas resources from tight reservoirs. Hydraulic fracturing techniques are also used in a variety of other applications that are unrelated to oil and gas production, includ‐ ing tunnel and dam construct...