Objective(s): K+ channel blocker 4-aminopyridine (4-AP) stimulates the release of glutamate from nerve terminals and induces seizures. Berberine as a potential herbal drug exerts several pharmacological actions on the central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate the effect of berberine on seizure onset and ti...

Background.  Many mechanisms are involved in pain transmission in the spinal cord.  Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia.  We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...

background: epidemic and endemic cholera is a major public health problem for many   countries. aim of this study was to evaluate ap-pcr for investigation of clonal relatedness among the strains of vibrio cholerae recovered from an out­break occurred in different parts of iran in 2005. methods: the study was conducted during the cholera outbreak occurred in some of provinces in iran in summer 2...

ten field isolates of mycoplasma gallisepticum (mg) from different geographical areas of iran were analyzed by random amplification of polymorphic dna (rapd). rapd analysis produced reproducible banding patterns on the basis of which various distinct amplification patterns could be detected. mg isolates compared with reference strains (s6 and mg ss) and vaccine strain (ts-11) and demonstrated d...