Chemically induced rat hepatocyte nodules and carcinomas have a reduced capacity to oxidize drugs. The reduction in monoxygenase activity results largely from the partial loss of cytochrome P-450, a heme-containing terminal electron acceptor. To determine whether the cytochrome P-450 deficit was indicative of an altered heme metabolism, we quantitated four heme-containing proteins in normal rat...

Clinicopathological, angiographie, and histological stud ies were made on liver neoplasms in adult male mongrel dogs after administration of diethylnitrosamine. Primary hepatic neoplasms of various types developed in 14 male mongrel dogs upon administration of diethylnitrosamine for over 50 weeks. Grossly, the surface of the liver of these animals appeared finely granular, rubbery, and hard. Si...

Chloroform and other trihalomethanes are contaminants of drinking water that have been demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of carcinogenicity of chloroform is required so that the animal data can be extrapolated to estimate the human health hazard. The extent of the binding of chloroform to rat liver and kidney DNA was approximately 0.1% the lev...