نتایج جستجو برای: diaphorase

تعداد نتایج: 1115  

Journal: :The Journal of experimental biology 1996
Elphick Williams Shea

The enzyme nitric oxide synthase can be localised by NADPH-diaphorase histochemistry. Here we have applied this technique to the optic lobe of the locust Schistocerca gregaria and revealed new features of the insect visual system. Extensive but locally intense staining is associated with identified tracts, distinct neuropiles and cell body groups, and a detailed analysis of stained elements is ...

Journal: :Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 2002
Juan J López-Costa Carolina Acuipil Patricia Tagliaferro Sameer Patel Javier Ramos Alicia Brusco Jorge Pecci Saavedra

NADPH-diaphorase is a useful technique to reveal NO producing neurons at light microscopic level (LM). A modification of the technique using the tetrazolium salt BSPT as substrate, is useful to study the ultrastructure of NO neurons. The aim of this work was to perform a detailed analysis of NADPH-diaphorase reactive neurons in rat mesencephalon both at light and electron microscopic levels. NA...

فتاحی, مریم, محمودیان, مسعود, نوبخت, ملیحه , شفیعی, معصومه , کهنه‌شهری, لیلا ,

Impaired endothelium-dependent relaxation of blood vessels is a common feature in diabetes but the exact underlying mechanisms have not yet been clarified. In the present study, endothelium-dependent vasorelaxation of aortic rings were evaluated in vitro in streptozocin-induced diabetic and age-matched control rats. Moreover, NO synthase activity of aortic endothelial cells was asse...

Journal: :Physiological research 2007
V Riljak M Milotová K Jandová J Pokorný M Langmeier

Using histochemical analysis (NADPH-diaphorase, Fluoro-Jade B dye and bis-benzimide 33,342 Hoechst) we studied the influence of intraperitoneal administration of nicotine (NIC), kainic acid (KA) and combination of both these substances on hippocampal neurons and their changes. In experiments, 35-day-old male rats of the Wistar strain were used. Animals were pretreated with 1 mg/kg of nicotine 3...

Journal: :Journal of Histochemistry & Cytochemistry 1966

Journal: :The Journal of pharmacology and experimental therapeutics 2013
Eugene Manley David J Waxman

We investigated the hypoxia-dependent cytotoxicity of AQ4N (banoxantrone) using a panel of 13 cancer cell lines and studied its relationship to the expression of the quinone reductase DT-diaphorase (NQO1), which is widely found in cancer cells. We also investigated pharmacologic treatments that increase tumor hypoxia in vivo and their impact on AQ4N chemosensitivity in a solid tumor xenograft m...

Journal: :Cancer research 1992
J M Silva D N Rao P J O'Brien

Trenimon belongs to a class of aziridinylbenzoquinone anticancer drugs that cross the blood-brain barrier. In this study we have investigated the molecular mechanisms for trenimon-induced toxicity in aerobic versus hypoxic conditions with the use of freshly isolated rat hepatocytes. The following evidence suggests the mechanisms for trenimon detoxification involves reduction by DT-diaphorase, w...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1997
J G Franca J L do-Nascimento C W Picanço-Diniz J A Quaresma A L Silva

We studied the distribution of NADPH-diaphorase activity in the visual cortex of normal adult New World monkeys (Saimiri sciureus) using the malic enzyme "indirect" method. NADPH-diaphorase neuropil activity had a heterogeneous distribution. In coronal sections, it had a clear laminar pattern that was coincident with Nissl-stained layers. In tangential sections, we observed blobs in supragranul...

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