Abstract Gap junctions are integral membrane proteins that play a role in cell-to-cell communication. They coded by the functional genes called connexins chordates and innexins invertebrates. However, recently pannexins were also found mammalian genomes, which homologous to insect innexins. junction intercellular communication (GJIC) has different functions ranging from their ontogenesis transf...

High-throughput screening of a subset of the CD3 chemical library (Centre for Drug Design and Discovery; KU Leuven) provided us with a lead compound 1, displaying low micromolar potency against dengue virus and yellow fever virus. Within a project aimed at discovering new inhibitors of flaviviruses, substitution of its central imidazole ring led to synthesis of variably substituted pyrazine dic...

Following our studies on the gastroprotective effect and cytotoxicity of terpene derivatives, new amides were prepared from the diterpene 8(17)-labden-15,19-dioic acid (junicedric acid) and its 8(9)-en isomer with C-protected amino acids (amino acid esters). The new compounds were evaluated for their gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice, as well as fo...