Canda et al. [1] focused on the changes of interstitial cells of Cajal (ICCs) and neuronal tissue related to diabetes. The results of the current study showed that the number of ICCs in the lamina propria and detrusor muscle is decreased in diabetic patients. This may be an underlying pathomechanism of lower urinary tract symptoms in patients with diabetes. Long lasting diabetes results in diff...

INTRODUCTION The aim of this study was to investigate the risk factors for distal symmetric sensory-motor polyneuropathy (DSP) in patients with type 2 diabetes mellitus (DM). METHOD Sixty seven patients with type 2 DM (33 males and 34 females) were included in the study. In addition to a detailed neurological examination, the Michigan Neuropathy Screening Instrument was administered to all pa...

TO THE EDITOR: Allen and colleagues (2) provided an in-depth review of the pathophysiology and functional outcomes of diabetic polyneuropathy (DPN) among patients with diabetes mellitus (DM). As explained (2), DPN often manifests in a symmetrical and length-dependent pattern affecting distal portions of long peripheral nerves of patients with DM (11). Here we highlight the molecular pathogenesi...

OBJECTIVE To test whether diabetic polyneuropathies (DPNs), retinopathy, or nephropathy is more prevalent in subjects with impaired glycemia (IG) (abnormality of impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired HbA(1c) [IA1C]) than in healthy subjects (non-IG). RESEARCH DESIGN AND METHODS Matched IG and non-IG volunteers were randomly identified from population-ba...

AIM The study was carried out to evaluate and compare the effect of low power, low frequency pulsed electromagnetic field (PEMF) of 600 and 800 Hz, respectively, in management of patients with diabetic polyneuropathy. SETTINGS AND DESIGNS The study was a randomized controlled trial performed in Guru Nanak Dev University and Medical College, Amritsar, India with different subject experimental ...

OBJECTIVE The diagnosis of diabetic sensorimotor polyneuropathy using objective electrophysiological tests is hindered by limited access to the specialized laboratories and technicians that perform and interpret them. We evaluated the performance characteristics of a novel portable and automated point-of-care nerve conduction study device, which can be operated by nontechnical personnel, and co...

The rising incidence of diabetes and its negative impact on quality of life highlights the urgent need to develop biomarkers of early nerve damage. Measurement of total vitamin B12 has some limitations. We want to determine the levels of urinary methylmalonic acid and its relationships with serum vitamin B12 and polyneuropathy. The 176 Chinese patients with Type 2 diabetes mellitus were divided...