Post thoracotomy chronic pain is a severe problem that affects the majority of patients and decreases the quality of life. The purpose of this study is to evaluate the long-term effects of thoracal epidural levobupivacaine and intravenous dexketoprofen analgesia formed pre-emptively on the wound site pain after major thoracotomy operations. This randomised, prospective and double-blind study wa...

OBJECTIVE Multimodal analgesic methods are preferred for the treatment of postoperative pain; as a result, the additive effects of analgesics are provided while probable side effects are avoided. The current study aimed to compare the effects of the combination of dexketoprofen and paracetamol with regard to postoperative pain therapy. METHODS Ninety-six patients who underwent non-malignant g...

Some nonsteroidal anti-inflammatory drugs (NSAIDs) have adverse effects on bone tissue. The objective of this study was to determine the effect of different doses of dexketoprofen, ketorolac, and metamizole on growth of the osteoblast MG63 cell line. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide spectrophotometry results showed that MG63 cell growth was significantly inhibited af...

BACKGROUND The objective was to study the antipyretic and hemodynamic effects of three different drugs used to treat fever in critically ill patients. METHODS DESIGN AND SETTING Prospective, observational study in a 16-bed, general ICU of a university hospital. PATIENT POPULATION We studied 150 patients who had a febrile episode (temperature>38°C): 50 received paracetamol, 50 metamizol a...

BACKGROUND Dexketoprofen has been shown to provide efficient analgesia and an opioid-sparing effect after orthopedic surgery. In this dose-finding study, we evaluated the analgesic efficacy and opioid-sparing effect of dexketoprofen administered intravenously (i.v.) after laparoscopic cholecystectomy (LCC). METHODS Twenty-four patients undergoing LCC were randomized to receive dexketoprofen 1...

OBJECTIVE This study was designed to compare the effects of dexketoprofen, lornoxicam, and diclophenac sodium on postoperative analgesia and tramadol consumption in patients receiving postoperative patient-controlled tramadol after a major abdominal surgery. METHODS Eighty patients were randomized to receive one of the four study drugs. Patients in group dexketoprofen (DT) received IV 50 mg d...

BACKGROUND Topical anesthesia is used to control pain associated with many procedures in medicine. Today, the product most commonly applied for topical anesthesia in Germany is EMLA® (lidocaine/prilocaine). However, since prilocaine is a methemoglobin-inducing agent, there are limitations to its use, especially in neonates and infants. The aim of this study was to evaluate the effect of priloca...

Objective: Although the length of hospital stay after lumbar microdiscectomy operations, one most common surgical interventions in current neurosurgery practice, is quite short, nausea-vomiting and urinary retention, particularly postoperative pain, may prolong this period. Also, systemic side effects occur cases due to pharmacological agents applied for pain control. This study was conducted s...