OBJECTIVE Oral submucous fibrosis (OSMF) is a premalignant condition of oral cavity characterized by inflammation and progressive mucosal fibrosis. It has questionable pathogenesis. Mast cells (MC) have been associated with variety of inflammatory and fibrotic conditions, but little is known about their role in OSMF. Mast cells have been studied in normal gingiva, chronic inflammatory gingiviti...

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the pat...

Linear IgA disease (LAD) is an acquired subepidermal bullous disorder, characterized by linear deposition of IgA along the basement membrane. Although the oral cavity is involved in up to 50% of cases, its exclusive involvement is very rare. The case of a 57-year-old woman with 13 months history of desquamative gingivitis chiefly located in the maxilla gingiva is presented. She had been diagnos...

Objectives: Mast cells play an important role in the pathogenesis of allergic and inflammatory diseases. This study aims to quantify mast cells in the gingival specimens of patients with desquamative gingivitis (DG) and chronic periodontitis (CP), and to compare it with clinically healthy gingiva (CHG). Materials and methods: 15 DG, and 15 CP and 15 CHG were included in the study. Histopatholog...

In xeroderma pigmentosum, a rare genodermatosis, transmitted as an autosomal recessive disorder, excessive solar damage to the skin develops at an early age. The disease is characterized by cutaneous, ocular, neurological and oral changes. Oral features in the form of early development of squamous cell carcinoma, usually at the lower lip and tip of the tongue may be seen. The disorder is associ...