BACKGROUND Recent concerns have been raised about the risk of gallbladder disease associated with the use of drospirenone, a fourth-generation progestin used in oral contraceptives. We conducted a study to determine the magnitude of this risk compared with other formulations of oral contraceptives. METHODS We conducted a retrospective cohort study using the IMS LifeLink Health Plan Claims Dat...

BACKGROUND AND PURPOSE Epidemiological studies have shown an increased risk of venous thrombosis in women taking third-generation oral contraceptives, ie, those containing the progestogens desogestrel or gestodene. This study assesses the risk of ischemic stroke with several types of oral contraceptives. METHODS A multicenter, population-based, case-control study was performed in 9 Dutch cent...

©FSRH J Fam Plann Reprod Health Care 2010: 36(3) Case report In December 2008, a 33-year-old, para 2 gravida 4, Caucasian woman presented to the sexual and reproductive health (SRH) community clinic requesting termination of pregnancy (TOP). This was an unintended pregnancy and she had been taking the progestogen-only pill (POP) etynodiol diacetate 500 μg (Femulen®) one tablet a day. The origin...

OBJECTIVE To measure the effect of 24 months of depot medroxyprogesterone acetate use on bone mineral density compared with oral contraception (pills) and nonhormonal contraception. METHODS Women aged 18-33 years self-selected oral contraception, depot medroxyprogesterone acetate, or nonhormonal contraception (controls). Those selecting pills were randomized to formulations containing either ...

Purpose: Steroid hormones in hormonal contraceptives influence a variety of metabolic parameters. Mainly, ethinyloestradiol (EE) combined (CHC) is potent inducer hepatic coagulation factors, has an impact on cholesterol and triglyceride levels glucose tolerance. Progestins CHC modify the oestrogen effects different ways, depending their pharmacologic properties. The progestin-only generally con...

Epidemiological studies indicate that use of third generation oral contraceptives increases the risk of venous thromboembolism more than does use of second generation oral contraceptives. Critics have suggested that this finding may be confounded by indication, since third generation pills were considered to be safer and were therefore perhaps prescribed more often to women at high risk. If con...

OBJECTIVE To compare complications of third and second generation oral contraceptive pills (OCPs). METHODS In a randomized clinical trial from October 2007 to October 2008, 100 healthy women of reproductive age referred to Amir Hospital Family Planning Clinic and some heath centers in Semnan, Iran were randomized in 2 equal groups. They received either a third generation OCP (150 microgram de...

PURPOSE The risk of venous thromboembolism (VTE) with drospirenone-containing oral contraceptives (OCs) is reviewed. SUMMARY Increasing attention and media have raised awareness and concern about whether drospirenone-containing OCs increase the risk of VTE. Two studies found that when compared with nonuse of OCs, use of drospirenone-containing OCs was associated with a fourfold to over sixfol...