PURPOSE The potential of desflurane to alter respiratory mechanics in the presence of bronchial hyperresponsiveness (BHR) is still a subject of debate. Accordingly, we evaluated the bronchoprotective potential of desflurane compared with sevoflurane following cholinergic lung constriction in rabbits with normal and hyperreactive airways. METHODS The input impedance of the respiratory system (...

We compared desflurane to propofol as the main anaesthetic in a balanced anaesthetic technique during elective arthroscopic day-case procedures with special reference to cost-effectiveness. A total of 80 ASA classification I patients were studied in a prospective randomised fashion. Surgery and anaesthesia were uneventful in all cases. Time spent in the recovery room and time to discharge was e...

Post-operative cognitive dysfunction (POCD) predominantly affects the elderly who suffer memory and concentration deficits after anesthesia and surgery. Animal studies have demonstrated anesthetic alone may contribute to POCD but results are variable and little is known about common anesthetics other than isoflurane. The present study investigated dose-dependence of desflurane anesthesia in you...

Desflurane, a newly introduced potent, inhaled anesthetic, differs from its predecessors in having a lower solubility in blood and tissues. The lower solubility imparts a greater control to the maintenance of anesthesia and a more rapid elimination and recovery from anesthesia. In other respects, the pharmacological properties of desflurane resemble those of its sister anesthetic, isoflurane, c...

conclusions the incidence of pocd was not significantly influenced by a bolus dose of ketamine (0.5 mg/kg) after orthopedic surgery in elderly patients. there were no negative effects of ketamine on early pocd. results the two groups had similar demographic characteristics except for the gender. surgical and anesthetic data were not significantly different. a statistically significant differenc...

Background Inhaled volatile anaesthetics remain the most widely used drugs for maintenance of general anaesthesia because of their ease of administration and predictable intraoperative and recovery characteristics. The result has been an increasing reliance on fluorinated anesthetics. The most recently introduced anesthetics, desflurane and sevoflurane, are ethers halogenated solely with fluori...

Demand is increasing for safer inhalational anesthetics for use in pediatric anesthesia. In this regard, researchers have debated whether isoflurane is more toxic to the developing brain than desflurane. In the present study, we compared the effects of postnatal exposure to isoflurane with those of desflurane on long-term cognitive performance and investigated the role of the Akt/GSK3β signalin...

The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. We hypothesized that endogenous estrogens play a role as mediators of desflurane-induced preconditioning against myocardial infarction. In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzym...

PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. An...

BACKGROUND Some studies suggest that behavioral complications of cholestasis, such as fatigue and pruritus, may be associated with altered neurotransmission in the brain. Because inhaled anesthetics primarily act on ion channels and receptors on the neuronal cell membrane and alter synaptic transmission in the central nervous system, it is possible that altered sensitivity to inhaled anesthetic...