The treatment of onychomycosis has improved considerably over the past several decades following the introduction of the oral antifungals terbinafine and itraconazole. However, these oral agents suffer from certain disadvantages, including drug interactions and potential liver toxicity. Thus, there is a need for new topical agents that are effective against onychomycosis. ME1111 is a novel sele...

Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the pl...

Background and Aims: Amino acids have different effects on the growth of some dermatophytes. Some may increase whereas others maydecrease their growth. The concentration of some amino acids is also an important factor for their effects. Materials and Methods: To investigate the effects of L-amino acids on the growth of six species of dermatophytes including Epidermophyton floccosum, Microspor...

Background:  Dermatophytes are common causes of cutaneous infections in humans and animals, which mostly reproduce by an asexual process. Such types of reproduction in many filamentous fungi are usually regulated by brlA, abaA, and wetA genes. The presence of these genes in dermatophytes was investigated.  Materials & Methods:   Conidiation genes represented by brlA, abaA, and wetA were dete...

Background: Griseofulvin is a fungistatic antifungal drug used to treat dermatophytosis. Dermatophytes that are often found include Trichophyton rubrum, mentagrophytes, Microsporum canis, gypseum, Epidermophyton floccosum. Purpose: This review article aims discuss the discovery of griseofulvin. Data Source: The author created this using literature study method relevant purpose review. Sources i...

It is unresolved as to whether fungi that share a common skin habitat might in principal interact. In in vitro screening tests with Candida albicans, Trichophytum rubrum and other common dermatophytes, we found C. albicans releases volatile compounds that inhibit growth of the dermatophytes. By applying (enantioselective) gas chromatography combined with mass spectrometry we identified 8 compou...

Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development. Although many published manuscripts describe resistance to azoles among yeast and molds, reports describing resistance of dermatophytes ar...

A total of 68 soil samples was collected from "favelas" (slums), schools, public squares, beaches and vacant lots in the city of João Pessoa-PB, Brazil. A search for dermatophytes in these soils was carried out by using the Vanbreuseghem technique. As a result, 48 strains and 6 dermatophytes species were isolated. Trichophyton terrestre (25.0%), Microsporum gypseum (20.8%) and Anthroderma gypse...

Cassia fistula is well known for its laxative and antifungal properties due to anthraquinone compounds in the pods. This study quantitatively analyzed rhein in the C. fistula pod pulp decoction extracts kept under various storage conditions using HPLC. The antifungal activity of the extracts and their hydrolyzed mixture was also evaluated against dermatophytes. The contents of rhein in all stor...