BACKGROUND Specific IgG4 induced by allergen-specific immunotherapy (SIT) is an immunological marker related to the appearance of clinical tolerance. But specific IgG4 levels in different age, gender and allergic disease populations have not been fully investigated. METHODS This study involved 226 children and 109 adults with allergic rhinitis and/or asthma receiving a 156-week course of Derm...

BACKGROUND Airway dendritic cells (DCs) are crucial for allergen-induced sensitization and inflammation in allergic asthma. After allergen challenge, an increased number of DCs is observed in airway epithelium from patients with allergy. OBJECTIVE Because Der p 1, a cysteine protease allergen from Dermatophagoides pteronyssinus , induces chemokine production by bronchial epithelial cells (BEC...

. Ist p eine Primzahl, so gilt für alle ganzen Zahlen a die Kongruenz a p ≡ a (mod p) (Folgerung aus dem Kleinen Fermatschen Satz). Mit der Eulerschen Phi-Funktion φ(n) gilt andererseits für beliebige teilerfremde ganze Zahlen n und a die Kongruenz aφ(n) ≡ 1 (mod n). 1797 begegnete der junge Gauss, in einem frühen Manuskript für ein nicht gedrucktes Schlusskapitel seiner Disquisitiones Arithmet...

Nach einer Einleitung und Diskussion tiber die Eingen­schaften der diabetischen Krankheiten wurde ausflihrlich trber die Aetiologie und Pathophysiologie der Zuckeran­kheiten,insbesondere der Altersdiabetis,gesprochen.Nach der symptomalogie der Diabetis haben wir die ncueste Einteilung der Zuckerkrankheiten genannt und die Untc­rsuchungsmethoden,die heute Uhlich sind,erwahnt;dazu wurden unsere M...

House dust mites (HDM) are the most common source of aeroallergens and in genetic susceptible individuals can cause symptoms ranging from atopic dermatitis to bronchial asthma. Der p 1, a major target of the human immune responses to HDM, through its enzymatic properties can modulate the adaptive immune system by the cleavage of CD23 and CD25. The consequences of this would be to promote allerg...

A prevalence study was conducted among office workers in Malaysia (N= 695). The aim of this study was to examine associations between asthma, airway symptoms, rhinitis and house dust mites (HDM) and cat allergy and HDM levels in office dust. Medical data was collected by a questionnaire. Skin prick tests were performed for HDM allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae)...

Dietary energy restriction (DER) inhibits experimentally induced mammary cancer, an effect accompanied by elevated levels of silent information regulator 2 (SIRT1), a class III histone deacetylase (HDAC). However, the effect of DER on targets of other classes of HDACs has not been reported, a highly relevant issue given evidence that HDAC induction favors the development of cancer and tumor gro...

BACKGROUND House dust mite allergens are the most important indoor allergens associated with asthma and rhinitis in Singapore and the tropics. Recent data to suggest that besides the Dermatophagoides spp., the domestic mite Blomia tropicalis (Bt) is also an important source of allergens in these regions. OBJECTIVE To evaluate the degree of allergenic cross-reactivity between Bt and D. pterony...