Distinguishing between major depressive disorder (MDD) and bipolar disorder is important because there are differences in the optimal management of these conditions. Antidepressant treatment of bipolar depression (BPD) can adversely affect long-term prognosis by causing destabilization of mood and more frequent depressive episodes, and can lead to the development of treatment resistance. Most p...

recent research from a number of clinical trials has shown that transdiagnostic cognitive-behavioral therapy is efficacious, having shown comparable effects on primary anxiety disorder diagnoses as traditional diagnosis-specific cbt, and highly economical for treatment providers. however, a majority of anxiety disorder patients present with two or more “comorbid” diagnoses at once. given that t...

BACKGROUND There is conflicting evidence about the influence of personality disorder on outcome in depressive disorders. AIMS Meta-analysis of studies in which a categorical assessment of personality disorder or no personality disorder was made in people with depressive disorders, and categorical outcome (recovered/not recovered) also determined. METHOD Systematic electronic search of the l...

In 1994, an estimated 6% of Canadians aged 18 and over—1.1 mi l l ion adults—experienced a Major Depressive Episode (MDE). Although depression is amenable to treatment, fewer than half (43%) the people who met the criteria of having experienced an MDE in the past year (approximately 487,000) reported talking to a health professional about their emotional or mental health. Furthermore, only 26% ...

BACKGROUND Approximately one-fifth of women present depression during pregnancy and puerperium, and almost 13% of pregnant women experience a major depressive disorder. OBJECTIVE The aim of this study was to identify risk factors for depression among pregnant women with a medical disorder and to evaluate the influence of depression on perinatal outcomes. METHODS Three hundred and twenty-six...

OBJECTIVES Optimal depression screening necessitates measurement tools that are valid across varied populations and in the presence of comorbidities. METHODS This study assessed the test properties of two versions of the Center for Epidemiologic Studies Depression scale against psychiatric diagnoses established by the Mini International Neuropsychiatric Interview among a clinical sample of US...

Depression is a complex psychiatric disorder that significantly impacts millions of individuals worldwide. Despite advances in our understanding its neurobiological underpinnings, treatment options remain limited, and not all patients respond adequately to available therapies. Emerging evidence has implicated brain-derived neurotrophic factor (BDNF), critical regulator neuronal plasticity, the ...

OBJECTIVE Previous research suggests that the comorbidity of major depression with a personality disorder, especially borderline personality disorder, is associated with a poorer response to ECT. The authors compared the acute outcome of ECT in depressed patients with borderline personality disorder, with personality disorders other than borderline personality disorder, and with no personality ...