Freight transport optimization, long based solely on an economic approach, happen today through the integration of environmental and/or social concerns, in line with the objectives of sustainable development. In the case of Small and Very Small Enterprises, these objectives cannot be reached individually, and these companies have to join their efforts to find collective solutions. Therefore, th...

Vehicle scheduling is the process of assigning vehicles to a set of predetermined trips with fixed starting and ending times, while minimizing capital and operating costs. This paper considers modeling, algorithmic, and computational aspects of the polynomially solvable case in which there is a single depot and vehicles are identical. A quasiassignment formulation is reviewed and an alternative...

In this study, we propose exact solution methods for the Split Delivery Vehicle Routing Problem (SDVRP). We first give a new vehicle-indexed flow formulation for the problem, and then, a relaxation obtained by aggregating the vehicle-indexed variables over all vehicles. This relaxation may have optimal solutions where several vehicles exchange loads at some customers. We cut-off such solutions ...

In the well-known Vehicle Routing Problem (VRP) a set of identical vehicles located at a central depot is to be optimally routed to supply customers with known demands subject to vehicle capacity constraints. An important variant of the VRP arises when a mixed fleet of vehicles, characterized by different capacities and costs, is available for distribution activities. The problem is known as Fl...

This paper deals with the ring star problem that consists in designing a ring that pass through a central depot, and then assigning each non visited customer to a node of the ring. The objective is to minimize the total routing and assignment costs. A new chain based formulation is proposed. Valid inequalities are proposed to strengthen the linear programming relaxation and are used as cutting ...

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug ...

We introduce a compact formulation for the fixed-destination multi-depot asymmetric travelling salesman problem (FD-mATSP). It consists of m salesmen distributed among D depots who depart from and return to their respective origins after visiting set customers. The proposed model exploits aspect by labelling arcs identify nodes that belong same tour. Our experimental investigation shows propose...

While oral naltrexone has a demonstrated ability to decrease alcohol reinforcement, it also has pharmacotherapeutic limitations, such as a small treatment effect size, adverse events, and plasma level fluctuations. The pharmacokinetic profile of naltrexone could be enhanced by intramuscular administration, which would sustain its release over several weeks and keep plasma levels relatively cons...

In this article, we propose a special case of two-echelon location-routing problem (2E-LRP) in cash-in-transit (CIT) sector. To tackle this realistic problem and to make the model applicable, a rich LRP considering several existing real-life variants and characteristics named BO-2E-PCLRPSD-TW including different objective functions, multiple echelons, multiple periods, capacitated vehicles, dis...