One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

non-steroidal anti-inflammatory drugs (nsaids) are the competitive inhibitors of cyclooxygenase (cox), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (pgs). their use is associated with the side effects such as gastrointestinal and renal toxicity. the therapeutic anti-inflammatory action of nsaids is produced by the inhibition of cox-2, while the ...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

Background: All cellular events depend upon the DNA synthesis and gene expression involving complex interplay between ligands such as interleukins and interferons, with various cell membrane receptors. These ligand-receptors interactions transmit signals within the cell via numerous signal transduction pathways to affect gene expression. Janus kinase/signal transducer and activator of transcrip...

background: gastric lavage (gl) is one of the most commonly used decontamination method for cholinergic insecticide ingestion in developing countries despite lack of supporting evidence. this study was designed to evaluate the outcome of patients with cholinergic insecticide poisoning treated with gl in regards to timing and frequency of the procedure. methods: in this prospective observational...

conclusions traditional medicine based on certain plants could be of beneficial effects in hypertension treatment. results in total, 52 species out of the 135 (39%) screened, gave more than 50% ace inhibition. forty species were found to possess a high ace inhibiting ability and were low in their tannin content. materials and methods in the present study 135 plants used in traditional persian m...

an experimental database is compiled in order to fingerprint the scales formed over the hot surfaces of heat exchangers, in cooling water systems or other systems with similar chemistry. to collect these data, a dynamic simulating pilot plant was designed with considerable application flexibility among which simultaneous flow of water with different velocity and heat fluxes to three simulating ...

abstract: objective(s): in recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, n1,n4-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological ef...

objective: to review the potential role and specific impact of statin drugs in women with pcos. the evidence for this use of statins in pcos is limited and still under further investigation. materials and methods: a search was conducted using pubmed, dynamed and pubmedhealth databases through october 16, 2016 using the terms polycystic ovary syndrome, pcos, hydroxymethylglutaryl-coa reductase i...