Based on the mechanism of pathophysiology, thalassemia major or transfusion-dependent thalassemia patients may have an increased risk of developing organic erectile dysfunction resulting from hypogonadism. However, there have been few studies investigating the association between erectile dysfunction and transfusion-naive thalassemia populations. We constructed a population-based cohort study t...

Background and aims: Thalassemia is one of the most prevalent hematologic disorders worldwide. Thalassemia is the most common inherited anemia and genetic disease. Diabetes mellitus and insulin resistance is one of the major endocrine problems in major thalassemia patients. This study was done to evaluate the association of serum γinterferon and IL-10 concentrations with insulin resistance in s...

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike patients with beta (β)-thalassemia major, do not require regular transfusion therapy for survival. The most commonly investigated forms are β-thalassemia intermedia, hemoglobin E/β-thalassemia, and α-thalassemia intermedia (hemoglobin H disease). However, transfusion-independence in such patients is not without ...

background: major thalassemia is the most common form of anemia requiring blood transfusion in iran. since ribavirin provokes anemia in the treated patients, interferon monotherapy may be an appropriate treatment in major thalassemic patients. the aim of this study was to determine the safety and efficacy of interferon monotherapy in thalassemic patients with hepatitis c virus infection. materi...

abstract β-thalassemia major (β –tm) is the most common thalassemia severe phenotype among iranians. in recent years, molecular understanding of pathogenesis of β –tm has provided a great opportunity regarding diagnostic issues. creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –tm and effective prenatal diagnosis (pnd) molecular screening tests. despit...

background: the most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. the aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in mofid hospital. materials and methods: there were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49...

This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact [email protected]...

Molecular defects responsible for β-thalassemias (thal) were investigated among 254 chromosomes from 127 transfusion-dependent unrelated thalassemic patients from two provinces in Northern Iraq. Among fourteen identified mutations, the seven most common found in 88.2% of the thal chromosomes were: IVS-II-1 (G → A), IVS-I-1 (G → A), codon 8 (-AA), codon 39 (G → T), codon 8/9 (+G), codon 44 (-C),...