Two inward rectifier potassium channels, the G protein-dependent GIRK1 and the G protein-independent BIR10, display large differences in rectification and macroscopic kinetics. A chimeric channel was constructed in which the putative intracellular carboxy-terminal domain of the G protein-dependent channel replaced the corresponding domain of the G protein-independent channel. The chimeric chann...

We investigated the sorption kinetics of pentachlorophenol (PCP) on soil at a pH of 4.1 using batch techniques. A multiple spiking methodology was employed to circumvent the solubility limitation of PCP. The ratio of sorbed PCP to solution-phase PCP (S/C) after 2-4 days of equilibration was concentration dependent. It decreased from 90 to 60 L/kg with a 4-fold increase in the total PCP concentr...

The time course of ethanol disappearance from the blood has been examined in normal males and females and in alcohol misusers. Blood alcohol estimations were made over a period of 3 hr, following an oral dose of ethanol (0.8 g/kg body weight) administered in the form of whisky. Attempts were made to fit the data to zero order, first order and mixed zero + first order kinetics. In the majority (...

The electric organ cells of Sternopygus generate action potentials whose durations vary over a fourfold range. This variation in action potential duration is the basis for individual variation in a communication signal. Thus, action potential duration must be precisely regulated in these cells. We had observed previously that the inactivation kinetics of the electrocyte Na(+) current show syste...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

in this study, residues of imidacloprid (confidor) were measured in greenhouse cucumbers in mazandaran province, iran. confidor 200 sl was applied at the recommended rate (30.0 g ai ha-1) and its double (60.0 g ai ha-1). samples were collected at 1 h to 21 days after application and analyzed to determine the content and dissipation rate of imidacloprid. . analysis was carried out by the quecher...

experiments were carried out in which the dependence of the fractional softening on temperature, time and strain rate was determined in a 304h stainless steel. three prestrain ranges were identified pertaining to three different post-deformation softening behaviors: 1) prestraining to below the drx critical strain: strongly strain dependent softening by srx alone with softening kinetics control...

Abstract Excitatory synaptic transmission in many neurons is mediated by two coexpressed ionotropic glutamate receptor subtypes, AMPA and NMDA receptors, that differ kinetics, ion selectivity, voltage-sensitivity. receptors have fast kinetics are voltage-insensitive, while slower increased conductance at depolarized membrane potentials. Here, we report the voltage dependency of act synergistica...