BACKGROUND Tuberculosis is a mycobacterial infection causing worldwide public health problems but the available vaccine is far from ideal. Type-1 T cell immunity has been shown to be critical for host defence against tuberculosis infection, but the role of dendritic cell (DC) subsets in pathogenesis of mycobacterial infection remains unclear. METHODOLOGY/PRINCIPAL FINDINGS We examined the eff...

BACKGROUND Atopic dermatitis (AD) and psoriasis represent polar immune diseases. AD is a T(H)2/T(H)22-dominant disease, whereas psoriasis is considered a T(H)1/T(H)17 disease. Local immune deviation is suggested to be regulated by dendritic cell (DC)-induced T-cell polarization and recruitment of specific T-cell subsets by chemokines. Although the role of chemokines is well documented, the actu...

Citation: Lee HK, Bae Y-S. 12th International Dendritic Cell Symposium, October 7–11, 2012; Daegu, Korea: New paradigm of dendritic cell science and application. OncoImmunology 2013; 2:e23245 The 12th International Dendritic Cell (DC) symposium (DC2012, www. DC2012.kr), organized by Ho-Youn Kim (President), Hyunah Lee (Secretary General), and Yong-Soo Bae (Scientific Program Organizer), was hel...

objective: dendritic cells (dcs) are essential for the activation and polarization of t cells during an adaptive immune response. in this research we investigated the effect of the lymphoide dcs pulsed with heat-treated tumor lysate (htl) as a vaccine in tumor immunotherapy. materials and methods: the balb/c mice were injected subcutaneously in the right flank with wehi-164 fibrosarcoma cells ...

objective: menstrual blood stromal stem cells (mbscs) share some phenotypic and functional similarities with mesenchymal stem cells (mscs). mscs are shown to inhibit either the function or generation of different immune cells, including dendritic cells (dcs). however, data regarding mbscs’ potential effects on immune system cells are elusive. here, we examine whether mbscs affect the generation...

Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is important for dendritic cell (DC) in migrating, recognizing, capturing, presenting antigens and in initiating T cell responses. In the present study, we investigated the role of DC-SIGN in renal tubulointerstitial inflammation and fibrosis. DC-SIGN was mainly expressed in tubular epithelial cells and DC-...

The predominant types of dendritic cells (DC) in the skin and mucosa are Langerhans cells (LC) and interstitial dermal DC (iDDC). LC and iDDC process cutaneous antigens and migrate out of the skin and mucosa to the draining lymph nodes to present antigens to T and B cells. Because of the strategic location of LC and iDDC and the ability of these cells to capture and process pathogens, we hypoth...

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.

BACKGROUND Sepsis is a multifactorial pathology with high susceptibility to secondary infections. Innate and adaptive immunity are affected in sepsis, including monocyte deactivation. METHODOLOGY/PRINCIPAL FINDINGS To better understand the effects of alterations in monocytes on the regulation of immune responses during sepsis, we analyzed their differentiation in dendritic cell (DC). Cells fr...

Background A variety of autologous tumor/dendritic-cell (DC) vaccines have been pursued. Our prior autologous tumor/ DC fusion (dendritoma) vaccine demonstrated clinical benefit in metastatic melanoma; however, dendritoma production is difficult and not scalable for commercialization. We developed an alternative, novel approach to efficiently deliver the autologous tumor antigenic repertoire to...