Multiple sclerosis affects every part of the neuraxis and has replaced syphilis as the great mimicker in neurology. In this article, the author describes the entire spectrum of multiple sclerosis signs and symptoms, focal and diffuse brain lesions, look-alike diseases, the overactive immune response, the complex pathology of demyelination, death and dysfunction of oligodendroglia and neurons, M...

Multiple sclerosis is a chronic inflammatory disease of the central nervous system, characterized by an aberrant activation of the immune system and combining demyelination with neurodegeneration. Studies on experimental models of multiple sclerosis revealed immunomodulatory and immunosuppressive properties of mesenchymal stem cells. Clinical trials using mesenchymal stem cells therapy in multi...

Demyelination is a characteristic hallmark of the neuro-inflammatory disease multiple sclerosis. During demyelination, macrophages phagocytose myelin and secrete inflammatory mediators that worsen the disease. Here, we investigated whether flavonoids, naturally occurring immunomodulating compounds, are able to influence myelin phagocytosis by macrophages in vitro. The flavonoids luteolin, querc...

OBJECTIVE Demyelination is a cardinal feature of multiple sclerosis, but it remains unclear why new lesions form, and whether they can be prevented. Neuropathological evidence suggests that demyelination can occur in the relative absence of lymphocytes, and with distinctive characteristics suggestive of a tissue energy deficit. The objective was to examine an experimental model of the early mul...

Introduction: Demyelination is one of the main causes of neurological disability. It is the end product of numerous pathological processes, multiple sclerosis (MS) being the most common cause. More than 70% of the MS patients suffer from optic disturbances. This disease commonly affects the optic pathway, particularly the optic nerves and chiasm. Several attempts have been made to produce a ...

BackgroundWidespread demyelination in the central nervous system can lead to progressive sensorimotor impairments following multiple sclerosis, with compromised postural stability during standing being a common consequence. As such, clinical strategies are needed improve sclerosis. The objective of this study was therefore investigate effect non-invasive transcutaneous spinal stimulation on upr...

Demyelinated lesions in the cerebral cortex and cortical atrophy have recently been recognized as important components of multiple sclerosis pathology. Although it has consistently been recognized in studies on the pathology of multiple sclerosis that demyelination may not only affect white matter but also the cortex and deep grey matter nuclei (Brownell and Hughes, 1962; Lumsden, 1970; Kidd et...

I believe that multiple sclerosis progression could be stopped through antibiotics, dewormers, beta glucans and garlic extract and, by far the most difficult, changing quality of water ingested, or used for washing salads, in addition to increasing consumption probiotics. MS is due unfortunate encounter 3 diseases: intestinal dysbiosis, chlamydia infections orthopedic problems. However, how wou...

conclusions our study suggests that the personality traits of patients with ms and healthy individuals are not significantly different. patients with ms are likely to use the same coping strategies as healthy individuals, except in the subscale of distancing. results no significant differences in personality characteristics were observed between patients and healthy controls (all p > 0.05). onl...