The sarcoglycan-sarcospan complex (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-SG-SSPN), a component of the dystrophin-associated glycoprotein complex (DAGC), is located at the sarcolemma of muscle fibers where it contributes to maintain cell integrity during contraction-relaxation cycles; gamma- and delta-SG are also expressed in the sarcoplasmic reticulum (SR). In this study, we report ...

Many DNA polymerases (Pol) have an intrinsic 3'-->5' exonuclease (Exo) activity which corrects polymerase errors and prevents mutations. We describe a role of the 3'-->5' Exo of Pol delta as a supplement or backup for the Rad27/Fen1 5' flap endonuclease. A yeast rad27 null allele was lethal in combination with Pol delta mutations in Exo I, Exo II, and Exo III motifs that inactivate its exonucle...

A comprehensive wind-tunnel test program on both a 65o delta an 80o/65o double delta wing model has been recently completed. The program included static and dynamic force tests. A brief description of the various experiments is presented, as well as results that demonstrate the value of the previously proposed "hypersurface" representation of aerodynamic loads in the non-linear and unsteady reg...

Much research is currently being carried out in the field of nanoelectronic circuit design [1], [2]. One of the proposed quantum devices is the Single Electron Tunneling (SET) device. This SET device consists of a tunnel junction, through which only an integer number of electrons can tunnel. A new local tunnel condition will be derived in this paper. The derivation is based on the discrete char...

The mitochondrial metabolism of 5-enoyl-CoAs, which are formed during the beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms, was studied with mitochondrial extracts and purified enzymes of beta-oxidation. Metabolites were identified spectrophotometrically and by high performance liquid chromatography. 5-cis-Octenoyl-CoA, a putative metabolite o...

Although Notch plays a crucial role in T cell development, regulation of Notch signaling in the thymus is not well understood. Kuzbanian, an ADAM protease, has been implicated in the cleavage of both Notch receptors and the Notch ligand, Delta. In this study we show that the expression of a dominant-negative form of Kuzbanian (dnKuz) leads to reduced TCRbeta expression in double-negative thymoc...

We present a simple derivation of the one-loop trace anomaly in spinor QED through dispersion relations, avoiding completely any ultraviolet regu-larization. The anomaly can be expressed as a convergent sum rule for the imaginary part of a relevant formfactor. In the massless limit, the imaginary part produces a delta-function singularity at zero external momentum squared. Such a treatment reve...

In this paper, we introduce difference double sequence spaces ${I_{2} }^{(\mu,\upsilon)}(M,\Delta)$ and ${I_{2}^{0}}^{(\mu,\upsilon)}(M,\Delta)$ in the intuitionistic fuzzy normed linear spaces. We also investigate some topological properties of these

Speech production is essentially a nonlinear dynamic process. Motivated by ideas in dynamic system research, this paper seeks to recast the speech representation problem (front-end) as an attempt to reconstruct the phase space of the production process, or articulatory configurations. We point out that the use of the delta and double delta features, common in current ASR (Automatic Speech Recog...