Limited cytoplasmic delivery of enzyme-susceptible drugs remains a significant challenge facing the development of protein and nucleic acid therapies that act in intracellular compartments. Researchers have examined several approaches, including fusogenic proteins and protein transduction domains, to enhance the intracellular delivery of the therapeutic cargo. This review summarises efforts to ...

Achieving traditional Byzantine agreement in the presence of arbitrary faults requires that the total number of nodes be larger than three times the number of faulty nodes. Two approaches have been proposed in the literature to circumvent this requirement: (i) hybrid fault model approach 4, 7] considers three types of faults of varying degree of severity, and (ii) degradable agreement approach ...

Forages help meet the protein requirements of ruminants by providing degraded CP for microbial protein synthesis plus protein that escapes ruminal degradation. Evidence from numerous feeding studies with lactating dairy cows indicates that excessive ruminal protein degradation may be the most limiting nutritional factor in higher-quality temperature legume forages. Hence, there is interest in i...

thirty multiparous holstein dairy cows with average body weights of 687±15 kg and body condition scores of 3.25±0.15 were allocated to 1 out of each 3 groups, immediately after parturition (dim=11) and in a completely randomized design. the first group was fed diet low in rumen undegradable protein (rup; 5.1% of dry matter), the second group fed with medium rup (7.2% of dry matter) while the th...

Cartilage defects in the knee are often seen in young and active patients. There is a need for effective joint preserving treatments in patients suffering from cartilage defects, as untreated defects often lead to osteoarthritis. Within the last two decades, tissue engineering based techniques using a wide variety of polymers, cell sources, and signaling molecules have been evaluated. We start ...

The current study proposed a topology optimization method accounting for base material degradation and create a degradable device that retains sufficient stiffness through the degradation process to provide load bearings for tissue regeneration in orthopaedic applications. Degradable materials are less stiff than permanent materials and suffer further stiffness reduction through time when consi...

Degradable quantum channels are among the only channels whose quantum and private classical capacities are known. As such, determining the structure of these channels is a pressing open question in quantum information theory. We give a comprehensive review of what is currently known about the structure of degradable quantum channels, including a number of new results as well as alternate proofs...

We have developed synthetic hydrogel extracellular matrix (ECM) analogues that can be used to study mechanisms involved in cell migration, such as receptor-ligand interactions and proteolysis. The biomimetic hydrogels consist of bioinert polyethylene glycol diacrylate derivatives with proteolytically degradable peptide sequences included in the backbone of the polymer and adhesive peptide seque...