D-eritadenine (DEA) is a potent inhibitor (IC(50) = 7 nm) of S-adenosyl-l-homocysteine hydrolase (AdoHcyase). Unlike cyclic sugar Ado analogue inhibitors, including mechanism-based inhibitors, DEA is an acyclic sugar Ado analogue, and the C2' and C3' have opposite chirality to those of the cyclic sugar Ado inhibitors. Crystal structures of DEA alone and in complex with AdoHcyase have been deter...

DEA models treat the DMU as a “black box.” Inputs enter and outputs exit, with no consideration of the intervening steps. Consequently, it is di(cult, if not impossible, to provide individual DMU managers with speci;c information regarding the sources of ine(ciency within their DMUs. We show how to use DEA to look inside the DMU, allowing greater insight as to the sources of organizational ine(...

In order to rationalize material selection in green design, this study presents an attempt combine the methods of generalized Data Envelopment Analysis (DEA) and Technique for Order Preference by Similarity Ideal Solution (TOPSIS). By establishing a index system, G-CCR model DEA was first used select effective materials from candidate samples, TOPSIS then sort suppliers. The combined DEA/TOPSIS...

data envelopment analysis (dea) is a non-parametric technique for evaluation of relative efficiency of decision making units described by multiple inputs and outputs. it is based on solving linear programming problems. since 1978 when basic dea model was introduced many its modifications were formulated. among them are two or multi-stage models with serial or parallel structure often called net...

Background: Literature abounds with various techniques for efficiency measurement of health care organizations (HCOs), which should be used cautiously and appropriately. The present study aimed at discovering the rules regulating the interplay among the number of inputs, outputs, and decision- making units (DMUs) and identifying all methods used for the measurement of Iranian HCOs and criticall...

Data envelopment analysis (DEA) is the leading technique for assessing the efficiency of decision making units (DMU) in the presence of multiple inputs and outputs. The two milestone DEA models, namely the CCR (Charnes et al., 1978) and the BCC (Banker et al., 1984) models have become standards in the literature of performance measurement. Recent applications of DEA include, among others, those...

data envelopment analysis (dea) is a nonparametric technique that includes models to evaluate the relative efficiency of decision making units (dmus). it has the ability to separate efficient units and inefficient units. one of the applications of this mathematical technique is evaluating performance of supply chain. according to such as the inefficiency factors of one dmu, is existence congest...

In this study, the data envelopment analysis (DEA), three-stage DEA (3SDEA) and artificial neural network (ANN) are employed to measure the technical efficiency of 29 semi-conductor firms in Taiwan. Estimated results show that there are significant differences in efficiency scores among DEA, 3SDEA and ANN analysis. The advanced setting of the three stages mechanism of DEA does show some changes...

ROBERT CAMPBELL, in honour of whose nmemory this lecture is held, was one of the great pioneers of aseptic surgery. He was the first surgeon to use rubber gloves in the British Isles, and he was responsible for many advances in our craft. He had a particular interest in the surgery of repair, and his appointment at the Children's Hospital gave him nmany opportunities to restore by means of repa...