Bambusae caulis in Liquamen (BCL), traditional herbal medicine used in East Asia, is known to have antioxidative and immune-regulating properties. We hypothesized that the potential antioxidant effects of BCL might suppress the production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in human keratinocytes (HaCaT cell). The immune-regulating effect o...

Organometallic complexes with thiopyrone-based ligands have shown promising cytotoxic activity in vitro. To investigate the impact of the ligand backbone modification of these biologically active compounds and enhance the solubility in aqueous solution, the (thio)pyrone scaffold was modified via Suzuki-Miyaura coupling reaction and converted into corresponding organometallic Ru(ii) and Rh(iii) ...

The objective of this study was to investigate the antioxidant and hepatoprotective effect of the chronic use of conventional (CGJ) or organic (OGJ) grape juice from the Bordeaux variety grape on oxidative stress and cytoarchitecture in the liver of rats supplemented with a high-fat diet (HFD) for three months. The results demonstrated that HFD induced an increase in thiobarbituric acid-reactiv...

Background: Ferroptosis is a new type of programmed cell death, which plays an important role in lung injury caused by sepsis. Studies have reported that Puerarin (Pue) can treat sepsis children, but whether it regulating iron death has not been reported. Methods: LPS induced human alveolar epithelial A549 to form model MTT detected the effect Pue on viability and LPS-induced viability. The eff...

The aim of the present study was to investigate effect swertiamarin (STM) in attenuating paraquat (PQ)-induced human lung alveolar epithelial-like cell (A549) apoptosis and underlying mechanisms. A549 cells were pretreated with different concentrations STM for 2 hr then cultured or without PQ (700 μM) 24 hr. Cell survival determined using CCK8 assay. Morphological changes, MDA content, inflamma...

Abstract Background Uraria picta ( Jacq. ) DC is a traditional Indian herb used in the Ayurvedic system of medicine. It an ingredient popular formulation “Dasamoola.” also traditionally as anti-inflammatory Ayurveda. The plant has excellent antioxidant potential. Different parts are useful and have diverse medicinal properties. present investigation was done to evaluate anticancer activity meth...

Distilled from the heartwood of Santalum album, Indian sandalwood oil is an essential that historically has been used as a natural active ingredient in cosmetics to condition and brighten skin. It documented exhibit antioxidant, anti-inflammatory, anti-proliferative activities. Here, we investigated protective anti-aging effects scavenging reactive oxygen species (ROS) HaCaT cells human skin ex...

Early events of stimulus-response coupling in polymorphonuclear leukocytes (PMNL) reportedly include membrane depolarization as a necessary antecedent to oxidative responses. However, depolarization by nonspecific means (ionophores) is insufficient to elicit an oxidative burst. This apparent conflict might be related to whether depolarization is due to membrane receptor-mediated stimulation of ...

BACKGROUND Serum paraoxonase 1 (PON1) is an oxidant-sensitive enzyme associated with high-density lipoprotein (HDL) that inhibits the atherogenic oxidation of low-density lipoprotein (LDL). In haemodialysis patients, production of reactive oxygen species, such as hypochlorous acid (HOCl) and hydrogen peroxide, is increased and serum PON1 arylesterase is abnormally low. We have examined the effe...

Incidents associated with methanol intoxication resulting from the consumption of fake wine occur not infrequently worldwide. Certain individuals are made blind due to methanol poisoning. The present study aimed to investigate the effects of sodium formate exposure on photoreceptor cells (661W cells). The 661W cells were exposed to sodium formate for 6‑24 h and cell viability was determined usi...