Introduction DCE-MRI has been widely used at 1.5T in a variety of organs and tissues. The aim of this study was to assess the feasibility of DCE-MRI in the liver at 3T, taking into account the challenges of 3T systems, and performed in such a way as to allow a dual-input pharmacokinetic analysis, separating the perfusion contributions from the hepatic artery and portal vein. To our knowledge, t...

OBJECTIVE The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla...

PURPOSE This pilot prospective study sought to determine whether dynamic contrast enhanced MRI (DCE-MRI) could be used as a clinical imaging biomarker of tissue toxicity from whole brain radiotherapy (WBRT). METHOD 14 patients who received WBRT were imaged using dynamic contrast enhanced DCE-MRI prior to and at 8-weeks, 16-weeks and 24-weeks after the initiation of WBRT. Twelve of the patient...

Three dimensional bilateral imaging is the standard for most clinical breast dynamic contrast-enhanced (DCE) MRI protocols. Because of high spatial resolution (sRes) requirement, the typical 1-2 min temporal resolution (tRes) afforded by a conventional full-k-space-sampling gradient echo (GRE) sequence precludes meaningful and accurate pharmacokinetic analysis of DCE time-course data. The comme...

Purpose This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers and to explore the possible pathological basis. Materials and Methods Approval from the institutional review board and informed consent were acquired for this study. The MR images of 104 patients with pat...

BACKGROUND Dynamic contrast-enhanced MRI (DCE-MRI) biomarkers have proven utility in tumors in evaluating microvascular perfusion and permeability, but it is unclear whether measurements made in different centers are comparable due to methodological differences. PURPOSE To evaluate how commonly utilized analytical methods for DCE-MRI biomarkers affect both the absolute parameter values and re...

BACKGROUND Pulmonary transit time (PTT) is an indirect measure of preload and left ventricular function, which can be estimated using the indicator dilution theory by contrast-enhanced ultrasound (CEUS). In this study, we first assessed the accuracy of PTT-CEUS by comparing it with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Secondly, we tested the hypothesis that PTT-CEUS c...

Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of a...

Introduction: Clinical, epidemiological and histological studies have indicated a link between vascular disease and osteoporosis (1). Dynamic contrast-enhanced MRI (DCE-MRI) provides a more direct measure of bone perfusion. DCE-MRI studies have consistently shown how semi-quantitative perfusion parameters are consistently reduced in osteopenic and osteoporotic bone compared to normal bone miner...

Differentiation between pancreatic carcinoma (PC) and mass-forming focal pancreatitis (FP) is invariably difficult. For the differential diagnosis, we qualitatively and quantitatively assessed the value of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in PC and FP in the present study. This study included 32 PC and 18 FP patients with histological confirmation who...