BACKGROUND For Parkinson's disease (PD), essential tremor (ET), and dystonia patients with deep brain stimulation (DBS) implants, magnetic resonance imaging (MRI) requires additional safety considerations due to potentially hazardous interactions. OBJECTIVE A propensity-matched cohort of DBS-implanted patients was analyzed to determine the likelihood of needing MRI. METHODS Patients with ne...

OBJECTIVE Deep brain stimulation (DBS) alleviates the cardinal Parkinson disease (PD) symptoms of tremor, rigidity, and bradykinesia. However, its effects on postural instability and gait disability (PIGD) are uncertain. Contradictory findings may be due to differences the in stimulation site and the length of time since DBS surgery. This prompted us to conduct the first meta-regression of long...

BACKGROUND Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicenter questionnaire study. METHODS Tinnitus was retrospectively assessed prior to DBS and at the cur...

Background: Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. However, the underlying mechanism of action of DBS remains unknown. The effect of DBS has been studied primarily by direct neural recording studies, which lack the ability to elucidate DBS related responses on a whole-brain scale. Functional Magnetic Resonance Imaging (fMRI) reflects ch...

AIMS To investigate whether deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) or the subthalamic nucleus (STN) improve lower urinary tract symptoms (LUTS) in advanced Parkinson's disease (PD). METHODS An exploratory post-hoc analysis was performed of specific LUTS items of questionnaires used in a randomized clinical trial with 128 patients (NSTAPS study). First, we compa...

Background First developed in France in 1987, Deep Brain Stimulation (DBS) is a neurosurgical intervention that involves the implantation of a brain pacemaker, which electrically stimulates specific brain nuclei.1 The FDA approved DBS for treatment for Essential Tremor in 1997, Parkinson’s Disease in 2002 and Dystonia in 2003.1 More recently, DBS has been indicated in management of neuropsychia...

Bilateral subthalamic nucleus deep brain stimulation (STN DBS) can reduce working memory while improving motor function in Parkinson disease (PD), but findings are variable. One possible explanation for this variability is that the effects of bilateral STN DBS on working memory function depend in part on functional or disease asymmetry. The goal of this study was to determine the relative contr...

The subthalamic nucleus (STN) occupies a strategic position in the motor network, slowing down responses in situations with conflicting perceptual input. Recent evidence suggests a role of the STN in emotion processing through strong connections with emotion recognition structures. As deep brain stimulation (DBS) of the STN in patients with Parkinson's disease (PD) inhibits monitoring of percep...

Although deep brain stimulation (DBS) shows promising efficacy as a therapy for intractable depression, the neurobiological bases underlying its therapeutic action remain largely unknown. The present study was aimed at characterizing the effects of infralimbic prefrontal cortex (IL-PFC) DBS on several pre-clinical markers of the antidepressant-like response and at investigating putative non-neu...

OBJECTIVES To provide current data for policy discussions and to assess future needs among newborn screening programs regarding the storage and use of residual dried blood spots (DBS) in the United States. STUDY DESIGN An electronic questionnaire was administered to U.S. state health department laboratory directors in 2003. RESULTS Responses were received from 49 of the 50 states. Approxima...